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Comment
. 2014 Dec;15(12):1097-8.
doi: 10.1038/ni.3029.

Systematic analysis of immunodeficiency

David F Tough  1
Affiliations
Comment

Systematic analysis of immunodeficiency

David F Tough. Nat Immunol. 2014 Dec.

Abstract

Humans deficient in the adaptor MyD88 or the kinase IRAK4 suffer from primary immunodeficiency. Blood cells from these patients show defective induction of specific subsets of genes after exposure to microbial stimuli in vitro.

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References

    1. Immunity. 2008 Jul 18;29(1):150-64 - PubMed
    1. Nat Rev Immunol. 2014 Aug;14(8):546-58 - PubMed
    1. Nature. 2010 Jun 17;465(7300):885-90 - PubMed
    1. Nat Immunol. 2014 Dec;15(12):1134-42 - PubMed
    1. Trends Immunol. 2011 Mar;32(3):104-9 - PubMed

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