ParadYm shift: Ym1 and Ym2 as innate immunological regulators of IL-17
- PMID: 25396344
- DOI: 10.1038/ni.3032
ParadYm shift: Ym1 and Ym2 as innate immunological regulators of IL-17
Abstract
Chitinase-like proteins are associated with type 2 immune responses and the ‘wound-healing’ pathway, but their role has remained unclear. Studies have now highlighted their contribution to IL-17 production and their link to neutrophil activity required for the control of helminth infection.
Comment on
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Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage.Nat Immunol. 2014 Dec;15(12):1116-25. doi: 10.1038/ni.3023. Epub 2014 Oct 19. Nat Immunol. 2014. PMID: 25326751 Free PMC article.
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