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. 2014 Nov 6:58:23353.
doi: 10.3402/fnr.v58.23353. eCollection 2014.

Nutritional status in patients with cutaneous leishmaniasis and a study of the effects of zinc supplementation together with antimony treatment

Miguel Guzman-Rivero  1 , Ernesto Rojas  2 , Aleida Verduguez-Orellana  2 , Henry Pardo  2 , Mary Cruz Torrico  3 , Lieselotte Cloetens  4 , Björn Akesson  5 , Edgar Sejas  3
Affiliations

Nutritional status in patients with cutaneous leishmaniasis and a study of the effects of zinc supplementation together with antimony treatment

Miguel Guzman-Rivero et al. Food Nutr Res. .

Abstract

Background: The role of micronutrient status for the incidence and clinical course of cutaneous leishmaniasis is not much studied. Still zinc supplementation in leishmaniasis has shown some effect on the clinical recovery, but the evidence in humans is limited.

Objective: To compare biochemical nutritional status in cutaneous leishmaniasis patients with that in controls and to study the effects of zinc supplementation for 60 days.

Design: Twenty-nine patients with cutaneous leishmaniasis were treated with antimony for 20 days. Fourteen of them got 45 mg zinc daily and 15 of them got placebo. Biomarkers of nutritional and inflammatory status and changes in size and characteristics of skin lesions were measured.

Results: The level of transferrin receptor was higher in patients than in controls but otherwise no differences in nutritional status were found between patients and controls. No significant effects of zinc supplementation on the clinical recovery were observed as assessed by lesion area reduction and characteristics or on biochemical parameters.

Conclusions: It is concluded that nutritional status was essentially unaffected in cutaneous leishmaniasis and that oral zinc supplementation administered together with intramuscular injection of antimony had no additional clinical benefit.

Keywords: antimony treatment; clinical chemistry; cutaneous leishmaniasis; nutritional biomarkers; zinc supplementation.

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Figures

Fig. 1
Fig. 1
Changes of the lesion area in patients with cutaneous leishmaniasis during the supplementation period with zinc or placebo. aBefore starting treatment, bend of antimony therapy, cend of supplementation period. Mann-Whitney test, p>0.05 at all time points.
Fig. 2
Fig. 2
Clinical characteristics of cutaneous leishmaniasis lesions in zinc or placebo supplemented groups (expressed as percent of occurrence). aStarting treatment, bend of antimony therapy, cend of supplementation period. Significant differences between groups at 20th day for purulent material and inflammatory halo (Chi-square test, p≤0.05).
See this image and copyright information in PMC

References

    1. World Health Organization. Geneva; 2010. Control of leishmaniasis: report of a meeting of the WHO expert committee on the control of leishmaniasis. http://www.who.int/iris/handle/10665/44412 [cited 19 January 2013].
    1. World Health Organization. Working to overcome the global impact of neglected tropical diseases. First WHO report on neglected tropical diseases. 2010. http://www.who.int/iris/handle/10665/44440 [cited 19 January 2013].
    1. Pan American Health Organization. Leishmaniasis: 2007 update. 2013. http_www.paho.org_leishmaniasis [cited 6 June 2013].
    1. Salehizadeh E, Nahrevanian H, Farahmand M, Hajihosseini R, Saghiri R, Khalili G. In vivo application of killed leishmania vaccine and imiquimod as adjuvant in Balb/c mice infected with Leishmania major MHRO/IR/75/ER as Iranian strain. Res J Parasitol. 2011;8:116–26.
    1. Rojas E, Parrado R, Delgado R, Reithinger R, Garcia AL. Leishmaniasis in Chaparé, Bolivia. Emerg Infect Dis. 2009;15:678–80. - PMC - PubMed