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Review
. 1989 Apr;58(4):207-10.
doi: 10.1007/BF00320775.

Osteosclerotic myeloma with polyneuropathy and hypocalcemia

C Ludescher  1 , K Grünewald, F Fend, O Dietze, J Thaler, K W Schmid
Affiliations
Review

Osteosclerotic myeloma with polyneuropathy and hypocalcemia

C Ludescher et al. Blut. 1989 Apr.

Abstract

A case is presented of a 46-year-old man with multifocal osteosclerotic bone lesions, peripheral polyneuropathy and hypocalcemia. Histologic examination of a bone marrow biopsy disclosed a multiple myeloma. Immunoelectrophoresis revealed a small M-component identified as IgG-lambda. Osteosclerotic myeloma lacking any osteolytic lesions seems to be very rare and shows several different features as compared with classical myeloma. A review of the current literature suggests that multiple myeloma is not a uniform disease but rather a group of clinical syndromes characterized by the special properties of their proliferating plasma cell clones.

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