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. 2015 Jan;32(1):103-6.
doi: 10.1007/s10815-014-0371-4. Epub 2014 Nov 16.

Association between a PD-1 gene polymorphism and antisperm antibody-related infertility in Iranian men

Mohammad Reza Zamani  1 , Firouzeh Akbari Asbagh, Amir Hossein Massoud, Arash Salmaninejad, Ahmad Massoud, Nima Rezaei
Affiliations

Association between a PD-1 gene polymorphism and antisperm antibody-related infertility in Iranian men

Mohammad Reza Zamani et al. J Assist Reprod Genet. 2015 Jan.

Abstract

Objective: Programmed cell death-1 (PD-1, Pdcd1), an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signalling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. This study investigates PD-1 gene polymorphism in patients with antisperm antibody-related infertility

Methods: Genotyping was performed by polymerase chain reaction and restriction enzyme digestion (PCR-RFLP), this polymorphism was genotyped in 145 Iranian subjects (61 patients with antisperm antibody-related infertility and 84 healthy controls).

Results: Patients frequencies of the G/A genotype in comparison with healthy controls (38.2 % vs. 32.7 %, OR =1.21, P = 0.35) were not significantly different. However, G/G and A/A genotype frequencies between patients and healthy controls were significantly different (P = 0.042, P = 0.00001, respectively). Also, allele frequencies of this polymorphism were significantly different (P = 0.0012) in patients compared to healthy controls.

Conclusion: According to these results, there is a correlation between PD-1 gene polymorphism and susceptibility to antisperm antibody-related infertility in our study group.

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