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. 2014 Aug 19;94(31):2452-4.

[Effects of rosuvastatin on arterial stiffness in hyperlipidemia patients]

[Article in Chinese]
Ping Wang  1 , Yingping Liu, Zuoyan Wang, Zhinan Wang, Nannan Zhao, Huiming Ye, Lihui Ren  2
Affiliations
  • PMID: 25400055

[Effects of rosuvastatin on arterial stiffness in hyperlipidemia patients]

[Article in Chinese]
Ping Wang et al. Zhonghua Yi Xue Za Zhi. .

Abstract

Objective: To evaluate the effects of rosuvastatin on arterial stiffness in hyperlipidemia patient without hypertension.

Methods: A total of 60 patients without hypertension received rosuvastatin (10 mg, n = 60) daily for 12 weeks while another 60 subjects used no statins. Brachial-ankle pulse wave velocity (ba-PWV), radial artery augmentation index of reflected wave (rAI) and metabolic index were measured before and after treatment.

Results: There were no significant change before and after non-statin treatment. Total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels decreased dramatically after resuvastin treatment [TC: (4.0 ± 1.0) vs (5.8 ± 1.1) mmol/L; LDL-C: (2.1 ± 0.7) vs (3.8 ± 0.7) mmol/L, both P < 0.01]. In rosuvastatin group, ba-PWV and rAI decreased significantly [ba-PWV: (1 340 ± 177) vs (1 477 ± 159) cm/s; rAI: (44 ± 13) % vs (57 ± 15) %, P < 0.01 and P < 0.05).

Conclusion: Atherosclerosis may be improved by rosuvastatin treatment in hyerlipidemia patient without hypertension.

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