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. 2014 Sep 15;7(10):7158-63.
eCollection 2014.

Association of p53 expression with prognosis in patients with esophageal squamous cell carcinoma

Wenjian Yao  1 , Xiuguang Qin  1 , Bo Qi  1 , Jianguo Lu  1 , Ling Guo  1 , Fulei Liu  1 , Shangguo Liu  1 , Baosheng Zhao  1
Affiliations

Association of p53 expression with prognosis in patients with esophageal squamous cell carcinoma

Wenjian Yao et al. Int J Clin Exp Pathol. .

Abstract

It has been well accepted that p53 overexpression is associated with advanced stages of cancer. However, the prognostic role of p53 overexpression in esophageal squamous cell carcinoma (ESCC) remains unclear. To investigate the prognostic role of p53 overexpression in patients with ESCC, a retrospective cohort study of 136 ESCC patients was carried out. The expression of p53 protein in tumor tissues was investigated immunohistochemically. Positive expression of p53 protein was detected in 57 ESCC patients (41.9%). The p53 overexpression was associated with smoking (P < 0.001), tumor differentiation (P < 0.001), and tumor size (P < 0.001). In the Kaplan-Meier analysis, patients with p53 overexpression had significantly shorter overall survival than those patients with negative p53 expression (log-rank P < 0.001). Multivariable analysis by Cox regression model further showed that p53 overexpression was a significantly independent predictor of poorer overall survival (hazard ratio [HR] = 1.91; 95% confidence interval [95% CI] 1.03-3.54, P = 0.04). Thus, p53 overexpression is associated with poor prognosis in patients with early stage esophageal squamous cell carcinoma, and it's a significantly independent predictor of poorer overall survival.

Keywords: Esophageal squamous cell carcinoma; p53; survival.

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Figure 1
Figure 1
Overall survival curve of patients in relation to p53 expression.
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References

    1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90. - PubMed
    1. Sharma A, Das BC, Sehgal A, Mehrotra R, Kar P, Sardana S, Phukan R, Mahanta J, Purkayastha J, Saxena S, Kapur S, Chatterjee I, Sharma JK. GSTM1 and GSTT1 polymorphism and susceptibility to esophageal cancer in high- and low-risk regions of India. Tumor Biol. 2013;34:3249–3257. - PubMed
    1. Lin Y, Totsuka Y, He Y, Kikuchi S, Qiao Y, Ueda J, Wei W, Inoue M, Tanaka H. Epidemiology of esophageal cancer in japan and china. J Epidemiol. 2013;23:233–242. - PMC - PubMed
    1. Zhu HC, Yang X, Xu LP, Zhao LJ, Tao GZ, Zhang C, Qin Q, Cai J, Ma JX, Mao WD, Zhang XZ, Cheng HY, Sun XC. Meat consumption is associated with esophageal cancer risk in a meat- and cancer-histological-type dependent manner. Dig Dis Sci. 2014;59:664–673. - PubMed
    1. Nakajima M, Kato H. Treatment options for esophageal squamous cell carcinoma. Expert Opin Pharmacother. 2013;14:1345–1354. - PubMed

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