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. 2014 Oct;5(10):1231-8.

Human herpesvirus-6 and epstein-barr virus infections at different histopathological grades of oral squamous cell carcinomas

Shirin Saravani  1 , Ebrahim Miri-Moghaddam  2 , Nima Sanadgol  3 , Hamideh Kadeh  1 , Mohammad Reza Nazeri  4
Affiliations

Human herpesvirus-6 and epstein-barr virus infections at different histopathological grades of oral squamous cell carcinomas

Shirin Saravani et al. Int J Prev Med. 2014 Oct.

Abstract

Background: The aim of this study was to determine the prevalence and viral load of Epstein-Barr virus (EBV) and Human herpesvirus-6 (HHV-6) in different histopathologic grades of oral squamous cell carcinoma (OSCC).

Methods: Forty-five formalin-fixed paraffin-embedded tissue section of OSCC patients were analyzed by quantitative real-time polymerase chain reaction for detection of EBV and HHV-6.

Results: The mean age of the patients was 58.6 years, 69% of whom were female, and 31% were male. Overall, the positive rate for EBV and HHV-6 were 16.7% and 27.1%, respectively; and the mean viral load EBV was 27.9 × 10(3) and 38.5 × 10(3) for HHV-6. No correlation was demonstrated between the viral load of EBV DNA (P = 0.35) and HHV-6 (P = 0.38) at the different OSCC histopathologic grades.

Conclusions: These findings neither lend support to the hypothesis that EBV and HHV-6 are directly involved in OSCC nor rule out the possibility that these viruses play an indirect role in carcinogenesis in this area.

Keywords: Epstein–Barr virus; herpesvirus-6; infection; oral cancer.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
The fluorescent quantitative real-time polymerase chain reaction amplification curve of Human herpesvirus-6
See this image and copyright information in PMC

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