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. 1989 Jan-Mar;74(1):1-3.

Cholangiocarcinoma in sclerosing cholangitis. The role of liver transplantation

A C Stieber  1 , I R Marino, S Iwatsuki, T E Starzl
Affiliations

Cholangiocarcinoma in sclerosing cholangitis. The role of liver transplantation

A C Stieber et al. Int Surg. 1989 Jan-Mar.

Abstract

Our experience with patients who underwent orthotopic liver transplantation for sclerosing cholangitis at the University of Pittsburgh Health Center between March 1980 and March 1988 is reported here. Ten patients had an associated cholangiocarcinoma. Six of these patients died of recurrent, disseminated cancer, usually before one year. One patient died of sepsis, while three are alive and apparently free of tumor four months to almost two years later. Pre-operative identification of a possible cholangiocarcinoma and complete resection are of crucial importance. Adjuvant therapy, especially pre-transplant radiation with a prophylactic purpose is still being evaluated.

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Figures

FIG. 1
FIG. 1
Percentages of sclerosing cholangitis patients with and without cholangiocarcinoma.
FIG. 2
FIG. 2
Survival of patients with cholangiocarcinoma (dotted/dash line) versus that of patients without cancer (solid line).
See this image and copyright information in PMC

References

    1. Kern F., jr . Primary sclerosing cholangitis. In: Leon, Schiff Eugene R., editors. Diseases of the Liver. 6. JB Lippincott Co; 1987. pp. 1454–1458.
    1. Cameron JL, Gayler BW, Sanfrey H, Milligan F, Kaufman S, Maddrey WC, Herlong HF. Sclerosing cholangitis. Anatomical distribution of obstructive lesions. Ann Surg. 1984;200:54–60. - PMC - PubMed
    1. LaRusso NF, Weisner RH, Ludwig J, et al. Primary sclerosing cholangitis. N Engl J Med. 1984;310:899–903. - PubMed
    1. Thompson HH, Pitt HA, Tompkins RK, et al. Primary sclerosing cholangitis. A heterogeneous disease. Ann Surg. 1982;196:127–136. - PMC - PubMed
    1. Weisner RH, LaRusso NF. Clinicopathologic features of the syndrome of primary sclerosing cholangitis. Gastroenterology. 1980;79:200–206. - PubMed

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