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Meta-Analysis
. 2014 Nov 18:15:376.
doi: 10.1186/1471-2474-15-376.

Lack of association of matrix metalloproteinase-3 gene polymorphism with susceptibility to rheumatoid arthritis: a meta-analysis

Zhitao Feng, Guochao He, Zhuanghong Chen, Zhengzhi Wu  1 , Juan Li
Affiliations
Meta-Analysis

Lack of association of matrix metalloproteinase-3 gene polymorphism with susceptibility to rheumatoid arthritis: a meta-analysis

Zhitao Feng et al. BMC Musculoskelet Disord. .

Abstract

Background: Epidemiological studies have investigated the association between matrix metalloproteinase-3(MMP-3) gene-1171 5A/6A polymorphism and rheumatoid arthritis (RA), but the results were inconsistent. To evaluate the specific relationship, we performed a meta-analysis to clarify the controversies.

Methods: The relevant literatures dated to December 07th 2013 were retrieved from PubMed, EMBASE and the China National knowledge Infrastructure (CNKI) databases. The number of the alleles and genotypes for MMP-3 were obtained. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the association between MMP-3 5A/6A promoter polymorphism and RA. All of the statistical analyses were conducted by STATA11.0 software.

Results: A total of 6 case-control studies covering 1451 cases and 1239 controls were included in the final meta-analysis. There was no significant association between MMP-3 5A/6A promoter polymorphism and RA in all genetic models (for 6A versus 5A: OR=1.19, 95% CI=0.91-1.56, P=0.203; 5A/6A versus 5A/5A: OR=1.31, 95% CI=0.89-1.92, P=0.174; 6A/6A versus 5A/5A: OR=1.78, 95% CI=0.68-4.61, P=0.238; the recessive model: OR=1.48, 95% CI=0.88-2.47, P=0.141; and the dominant model: OR=1.46, 95% CI=0.71-3.00, P=0.299). In the subgroup analysis by ethnicity, we obtained the similar results.

Conclusions: We systematically investigate the association between MMP-3-1171 5A/6A polymorphism and RA susceptibility; however, the results show a lack of correlation. Considering the small sample size and the selection bias existed in some studies, further studies are needed to confirm the findings.

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Figures

Figure 1
Figure 1
Flow diagram of selected of studies and specific reasons for exclusion from the meta-analysis.
Figure 2
Figure 2
Funnel plots of the association between MMP-3-1171 5A/6A polymorphism and RA. A (alleles model: 6A vs 5A), B (alleles model:5A/6A vs 5A/5A), C (alleles model: 6A/6A vs 5A/5A), D (Recessive model: 6A/6A versus 5A/5A +5A/6A) and E (Dominant model: 6A/6A +5A/6A vs 5A/5A).
See this image and copyright information in PMC

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Pre-publication history
    1. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2474/15/376/prepub

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