Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Nov 17;211(12):2327-8.
doi: 10.1084/jem.21112insight3.

Immunotherapy and the belly of the beast

Taha Merghoub  1 , Jedd D Wolchok  1
Affiliations
Comment

Immunotherapy and the belly of the beast

Taha Merghoub et al. J Exp Med. .
No abstract available

PubMed Disclaimer

Figures

None
Insight from Taha Merghoub (left) and Jedd Wolchok (right)
None
The Murphy group previously showed that immunotherapy with anti-CD40 and IL-2 leads to a productive immune response in young mice (A) but lethal cytokine storm in older mice (B). They now find that the visceral fat that accumulates in aged mice (or young obese mice) is the primary trigger of inflammation after immunotherapy, resulting in increased inflammatory M1 macrophages and toxic cytokine storm (B). Immunotherapy-induced lethality was prevented by blocking TNF or depleting macrophages (B). Whether the success of immunotherapy in the treatment of tumor-bearing mice will also be impaired by obesity remains to be determined.
See this image and copyright information in PMC

Comment on

References

    1. Mirsoian, A., et al. 2014. J. Exp. Med. 10.1084/jem.20140116. - DOI