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Review
. 2015 Jan;16(1):468.
doi: 10.1007/s11934-014-0468-4.

Reprogramming of prostate cancer cells--technical challenges

Gisely T Borges  1 , Eneida F Vêncio, Ricardo Z N Vêncio, Robert L Vessella, Carol B Ware, Alvin Y Liu
Affiliations
Review

Reprogramming of prostate cancer cells--technical challenges

Gisely T Borges et al. Curr Urol Rep. 2015 Jan.

Abstract

Prostate cancer progression is characterized by tumor dedifferentiation. Cancer cells of less differentiated tumors have a gene expression/transcriptome more similar to that of stem cells. In dedifferentiation, cancer cells may follow a specific program of gene expression changes to a stem-like state. In order to treat cancer effectively, the stem-like cancer cells and cancer differentiation pathway need to be identified and studied. Due to the very low abundance of stem-like cancer cells, their isolation from fresh human tumors is technically challenging. Induced pluripotent stem cell technology can reprogram differentiated cells into stem-like, and this may be a tool to generate sufficient stem-like cancer cells.

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References

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