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Review
. 2014:2014:869604.
doi: 10.1155/2014/869604. Epub 2014 Oct 22.

Update on intra-arterial chemotherapy for retinoblastoma

Mario Zanaty  1 , Guilherme Barros  1 , Nohra Chalouhi  1 , Robert M Starke  2 , Philip Manasseh  1 , Stavropoula I Tjoumakaris  1 , Carol L Shields  3 , David Hasan  4 , Ketan Bulsara  5 , Robert H Rosenwasser  1 , Pascal Jabbour  6
Affiliations
Review

Update on intra-arterial chemotherapy for retinoblastoma

Mario Zanaty et al. ScientificWorldJournal. 2014.

Abstract

The tools for managing retinoblastoma have been increasing in the past decade. While globe-salvage still relies heavily on intravenous chemotherapy, tumors in advanced stage that failed chemotherapy are now referred for intra-arterial chemotherapy (IAC) to avoid enucleation. However, IAC still has many obstacles to overcome. We present an update on the indications, complications, limitations, success, and technical aspects of IAC. Given its safety and high efficacy, it is expected that IAC will replace conventional strategies and will become a first-line option even for tumors that are amenable for other strategies.

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Figures

Figure 1
Figure 1
Fundoscopic exam revealing an intraocular retinoblastoma before treatment with intra-arterial chemotherapy.
Figure 2
Figure 2
Digital subtraction angiography showing superselective catheterization with melphalan injection of the ophthalmic artery.
Figure 3
Figure 3
Fundoscopic exam revealing the same patient with intraocular retinoblastoma after treatment with intra-arterial chemotherapy.
See this image and copyright information in PMC

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