Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Dec 17;5(12):1146-7.
doi: 10.1021/cn500285h. Epub 2014 Nov 18.

Are we using the right pharmacological tools to target EphA4?

Massimiliano Tognolini  1 , Matteo Incerti, Alessio Lodola
Affiliations
Review

Are we using the right pharmacological tools to target EphA4?

Massimiliano Tognolini et al. ACS Chem Neurosci. .

Abstract

The EphA4 receptor has been proposed to be a key actor in neurodegenerative diseases. In the last years, several research groups focused their efforts on the discovery of small molecules capable of blocking EphA4 activity by binding its extracellular domain. However, none of the compounds so far identified possess adequate chemical and/or pharmacological profiles to assess the "druggability" of EphA4 in animal models. New efforts are required to deliver a new generation of suitable pharmacological tools.

Keywords: Eph-ephrin antagonist; EphA4; Rhynchophylline; UniPR129; compound 1.

PubMed Disclaimer