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Review
. 2015 Feb 15;24(4):417-25.
doi: 10.1089/scd.2014.0331. Epub 2014 Dec 31.

microRNAs as regulators of adipogenic differentiation of mesenchymal stem cells

Dana Hamam  1 , Dalia Ali, Moustapha Kassem, Abdullah Aldahmash, Nehad M Alajez
Affiliations
Review

microRNAs as regulators of adipogenic differentiation of mesenchymal stem cells

Dana Hamam et al. Stem Cells Dev. .

Abstract

microRNAs (miRNAs) constitute complex regulatory network, fine tuning the expression of a myriad of genes involved in different biological and physiological processes, including stem cell differentiation. Mesenchymal stem cells (MSCs) are multipotent stem cells present in the bone marrow stroma, and the stroma of many other tissues, and can give rise to a number of mesoderm-type cells including adipocytes and osteoblasts, which form medullary fat and bone tissues, respectively. The role of bone marrow fat in bone mass homeostasis is an area of intensive investigation with the aim of developing novel approaches for enhancing osteoblastic bone formation through inhibition of bone marrow fat formation. A number of recent studies have reported several miRNAs that enhance or inhibit adipogenic differentiation of MSCs and with potential use in microRNA-based therapy to regulate adipogenesis in the context of treating bone diseases and metabolic disorders. The current review focuses on miRNAs and their role in regulating adipogenic differentiation of MSCs.

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Figures

<b>FIG. 1.</b>
FIG. 1.
Regulation of runt-related transcription factor 2 (RUNX2) by miR-204/211, miR-30, and miR-320 family. During adipocytic differentiation of mesenchymal stem cells (MSCs), members of the miR-204/211, miR-30, and miR-320 family are upregulated, which subsequently repress RUNX2 and promote adipogenesis. Color images available online at www.liebertpub.com/scd
See this image and copyright information in PMC

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