Regional differences in heart failure with preserved ejection fraction trials: when nephrology meets cardiology but east does not meet west

Affiliations

¹ From Inserm, Centre d'Investigations Cliniques-Plurithématique 1433 and Inserm U1116, Nancy, France (P.R., F.Z.); CHU Nancy, Département de Cardiologie, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy, Nancy, France (P.R., F.Z.); Université de Lorraine, Nancy, France (P.R., F.Z.); and INI-CRCT (Cardiovascular and Renal Clinical Trialists), French-Clinical Research Infrastructure Network (F-CRIN), Nancy, France (P.R., F.Z.). p.rossignol@chu-nancy.fr.
² From Inserm, Centre d'Investigations Cliniques-Plurithématique 1433 and Inserm U1116, Nancy, France (P.R., F.Z.); CHU Nancy, Département de Cardiologie, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy, Nancy, France (P.R., F.Z.); Université de Lorraine, Nancy, France (P.R., F.Z.); and INI-CRCT (Cardiovascular and Renal Clinical Trialists), French-Clinical Research Infrastructure Network (F-CRIN), Nancy, France (P.R., F.Z.).

Editorial

Patrick Rossignol et al. Circulation. 2015.

. 2015 Jan 6;131(1):7-10.

doi: 10.1161/CIRCULATIONAHA.114.013637. Epub 2014 Nov 18.

¹ From Inserm, Centre d'Investigations Cliniques-Plurithématique 1433 and Inserm U1116, Nancy, France (P.R., F.Z.); CHU Nancy, Département de Cardiologie, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy, Nancy, France (P.R., F.Z.); Université de Lorraine, Nancy, France (P.R., F.Z.); and INI-CRCT (Cardiovascular and Renal Clinical Trialists), French-Clinical Research Infrastructure Network (F-CRIN), Nancy, France (P.R., F.Z.). p.rossignol@chu-nancy.fr.
² From Inserm, Centre d'Investigations Cliniques-Plurithématique 1433 and Inserm U1116, Nancy, France (P.R., F.Z.); CHU Nancy, Département de Cardiologie, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy, Nancy, France (P.R., F.Z.); Université de Lorraine, Nancy, France (P.R., F.Z.); and INI-CRCT (Cardiovascular and Renal Clinical Trialists), French-Clinical Research Infrastructure Network (F-CRIN), Nancy, France (P.R., F.Z.).

No abstract available

Keywords: Editorials; aldosterone; clinical trials as topic; heart failure; kidney function; mineralocorticoids; ventricular function, left.

Comment on

Regional variation in patients and outcomes in the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) trial.
Pfeffer MA, Claggett B, Assmann SF, Boineau R, Anand IS, Clausell N, Desai AS, Diaz R, Fleg JL, Gordeev I, Heitner JF, Lewis EF, O'Meara E, Rouleau JL, Probstfield JL, Shaburishvili T, Shah SJ, Solomon SD, Sweitzer NK, McKinlay SM, Pitt B. Pfeffer MA, et al. Circulation. 2015 Jan 6;131(1):34-42. doi: 10.1161/CIRCULATIONAHA.114.013255. Epub 2014 Nov 18. Circulation. 2015. PMID: 25406305 Clinical Trial.
International geographic variation in event rates in trials of heart failure with preserved and reduced ejection fraction.
Kristensen SL, Køber L, Jhund PS, Solomon SD, Kjekshus J, McKelvie RS, Zile MR, Granger CB, Wikstrand J, Komajda M, Carson PE, Pfeffer MA, Swedberg K, Wedel H, Yusuf S, McMurray JJ. Kristensen SL, et al. Circulation. 2015 Jan 6;131(1):43-53. doi: 10.1161/CIRCULATIONAHA.114.012284. Epub 2014 Nov 18. Circulation. 2015. PMID: 25406306 Clinical Trial.