Observational Study

. 2015 Mar;16(3):152-60.

doi: 10.1111/hiv.12188. Epub 2014 Nov 18.

HIV and aging: insights from the Asia Pacific HIV Observational Database (APHOD)

N Han¹, S T Wright, C C O'Connor, J Hoy, S Ponnampalavanar, M Grotowski, H X Zhao, A Kamarulzaman; Australian HIV Observational Database (AHOD); TREAT Asia HIV Observational Database (TAHOD)

Collaborators, Affiliations

Collaborators

C V Mean, V Saphonn, K Vohith, F J Zhang, H X Zhao, N Han, P C K Li, M P Lee, N Kumarasamy, S Saghayam, C Ezhilarasi, S Pujari, K Joshi, A Makane, T P Merati, D N Wirawan, F Yuliana, E Yunihastuti, D Imran, A Widhani, S Oka, J Tanuma, T Nishijima, J Y Choi, S Na, J M Kim, C K C Lee, B L H Sim, R David, A Kamarulzaman, S F Syed Omar, S Ponnampalavanar, I Azwa, R Ditangco, E Uy, R Bantique, W W Wong, W W Ku, P C Wu, O T Ng, P L Lim, L S Lee, M T Tan, P Phanuphak, K Ruxrungtham, A Avihingsanon, P Chusut, S Kiertiburanakul, S Sungkanuparph, L Chumla, N Sanmeema, R Chaiwarith, T Sirisanthana, W Kotarathititum, J Praparattanapan, P Kantipong, P Kambua, W Ratanasuwan, R Sriondee, V K Nguyen, V H Bui, T T Cao, T T Pham, D D Cuong, H L Ha, A H Sohn, N Durier, B Petersen, D A Cooper, M G Law, A Jiamsakul, D Boettiger, D Ellis, M Bloch, T Franic, S Agrawal, L McCann, N Cunningham, T Vincent, D Allen, J L Little, D Smith, C Gray, D Baker, R Vale, D J Templeton, C O'Connor, Dijanosic, E Jackson, K McCallum, M Grotowski, S Taylor, D Cooper, A Carr, F Lee, K Hesse, K Sinn, R Norris, R Finlayson, I Prone, E Jackson, J Shakeshaft, K Brown, C McGrath, V McGrath, S Halligan, L Wray, P Read, H Lu, D Couldwell, D Smith, V Furner, J Watson, C Lawrence, B Mulhall, M Law, K Petoumenos, S Wright, H McManus, C Bendall, M Boyd, A Kulatunga, P Knibbs, J Chuah, M Ngieng, B Dickson, D Russell, S Downing, D Sowden, J Broom, K Taing, C Johnston, K McGill, D Orth, D Youds, M Kelly, A Gibson, H Magon, W Donohue, R Moore, S Edwards, R Liddle, P Locke, N J Roth, J Nicolson, H Lau, T Read, J Silvers, W Zeng, J Hoy, K Watson, M Bryant, S Price, I Woolley, M Giles, T Korman, J Williams, D Nolan, J Skett, J Robinson

Affiliation

¹ Beijing Ditan Hospital, Capital Medical University, Beijing, China.

PMID: 25407085
PMCID: PMC4884770
DOI: 10.1111/hiv.12188

Observational Study

HIV and aging: insights from the Asia Pacific HIV Observational Database (APHOD)

N Han et al. HIV Med. 2015 Mar.

. 2015 Mar;16(3):152-60.

doi: 10.1111/hiv.12188. Epub 2014 Nov 18.

Authors

N Han¹, S T Wright, C C O'Connor, J Hoy, S Ponnampalavanar, M Grotowski, H X Zhao, A Kamarulzaman; Australian HIV Observational Database (AHOD); TREAT Asia HIV Observational Database (TAHOD)

Collaborators

C V Mean, V Saphonn, K Vohith, F J Zhang, H X Zhao, N Han, P C K Li, M P Lee, N Kumarasamy, S Saghayam, C Ezhilarasi, S Pujari, K Joshi, A Makane, T P Merati, D N Wirawan, F Yuliana, E Yunihastuti, D Imran, A Widhani, S Oka, J Tanuma, T Nishijima, J Y Choi, S Na, J M Kim, C K C Lee, B L H Sim, R David, A Kamarulzaman, S F Syed Omar, S Ponnampalavanar, I Azwa, R Ditangco, E Uy, R Bantique, W W Wong, W W Ku, P C Wu, O T Ng, P L Lim, L S Lee, M T Tan, P Phanuphak, K Ruxrungtham, A Avihingsanon, P Chusut, S Kiertiburanakul, S Sungkanuparph, L Chumla, N Sanmeema, R Chaiwarith, T Sirisanthana, W Kotarathititum, J Praparattanapan, P Kantipong, P Kambua, W Ratanasuwan, R Sriondee, V K Nguyen, V H Bui, T T Cao, T T Pham, D D Cuong, H L Ha, A H Sohn, N Durier, B Petersen, D A Cooper, M G Law, A Jiamsakul, D Boettiger, D Ellis, M Bloch, T Franic, S Agrawal, L McCann, N Cunningham, T Vincent, D Allen, J L Little, D Smith, C Gray, D Baker, R Vale, D J Templeton, C O'Connor, Dijanosic, E Jackson, K McCallum, M Grotowski, S Taylor, D Cooper, A Carr, F Lee, K Hesse, K Sinn, R Norris, R Finlayson, I Prone, E Jackson, J Shakeshaft, K Brown, C McGrath, V McGrath, S Halligan, L Wray, P Read, H Lu, D Couldwell, D Smith, V Furner, J Watson, C Lawrence, B Mulhall, M Law, K Petoumenos, S Wright, H McManus, C Bendall, M Boyd, A Kulatunga, P Knibbs, J Chuah, M Ngieng, B Dickson, D Russell, S Downing, D Sowden, J Broom, K Taing, C Johnston, K McGill, D Orth, D Youds, M Kelly, A Gibson, H Magon, W Donohue, R Moore, S Edwards, R Liddle, P Locke, N J Roth, J Nicolson, H Lau, T Read, J Silvers, W Zeng, J Hoy, K Watson, M Bryant, S Price, I Woolley, M Giles, T Korman, J Williams, D Nolan, J Skett, J Robinson

Affiliation

¹ Beijing Ditan Hospital, Capital Medical University, Beijing, China.

PMID: 25407085
PMCID: PMC4884770
DOI: 10.1111/hiv.12188

Abstract

Objectives: The proportion of people living with HIV/AIDS in the ageing population (>50 years old) is increasing. We aimed to explore the relationship between older age and treatment outcomes in HIV-positive persons from the Asia Pacific region.

Methods: Patients from the Australian HIV Observational Database (AHOD) and the TREAT Asia HIV Observational Database (TAHOD) were included in the analysis. We used survival methods to assess the association between older age and all-cause mortality, as well as time to treatment modification. We used regression analyses to evaluate changes in CD4 counts after combination antiretroviral therapy (cART) initiation and determined the odds of detectable viral load, up to 24 months of treatment.

Results: A total of 7142 patients were included in these analyses (60% in TAHOD and 40% in AHOD), of whom 25% were >50 years old. In multivariable analyses, those aged > 50 years were at least twice as likely to die as those aged 30-39 years [hazard ratio (HR) for 50-59 years: 2.27; 95% confidence interval (CI) 1.34-3.83; HR for > 60 years: 4.28; 95% CI 2.42-7.55]. The effect of older age on CD4 count changes was insignificant (p-trend=0.06). The odds of detectable viral load after cART initiation decreased with age (p-trend=< 0.0001). The effect of older age on time to first treatment modification was insignificant (p-trend=0.21). We found no statistically significant differences in outcomes between AHOD and TAHOD participants for all endpoints examined.

Conclusions: The associations between older age and typical patient outcomes in HIV-positive patients from the Asia Pacific region are similar in AHOD and TAHOD. Our data indicate that 'age effects' traverse the resource-rich and resource-limited divide and that future ageing-related findings might be applicable to each setting.

Keywords: Asia Pacific; HIV infection; ageing; combination antiretroviral therapy; older patients; outcomes.

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Figures

**Figure 1. The association of the hazard ratio for all cause mortality with age stratified by cohort**
AHOD, Australian HIV Observational Database; CI confidence interval; TAHOD, TREAT Asia HIV Observational Database.

**Figure 2. Association of odds ratio of detectable HIV RNA viral load with age stratified by cohort**
AHOD, Australian HIV Observational Database; CI, confidence interval; TAHOD, TREAT Asia Observational Database.

See this image and copyright information in PMC

References

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HIV and aging: insights from the Asia Pacific HIV Observational Database (APHOD)

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HIV and aging: insights from the Asia Pacific HIV Observational Database (APHOD)

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