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Randomized Controlled Trial
. 2014 Nov 18:14:180.
doi: 10.1186/1471-2466-14-180.

Exercise training for asbestos-related and other dust-related respiratory diseases: a randomised controlled trial

Marita T Dale  1 , Zoe J McKeough, Phillip A Munoz, Peter Corte, Peter T P Bye, Jennifer A Alison
Affiliations
Randomized Controlled Trial

Exercise training for asbestos-related and other dust-related respiratory diseases: a randomised controlled trial

Marita T Dale et al. BMC Pulm Med. .

Abstract

Background: The study aimed to determine the short and long-term effects of exercise training on exercise capacity and health-related quality of life (HRQoL) compared to usual care in people with dust-related pleural and interstitial respiratory diseases. No previous studies have specifically evaluated exercise training in this patient population.

Methods: Participants with a diagnosis of a dust-related respiratory disease including asbestosis and asbestos related pleural disease were recruited and randomised to an eight-week exercise training group (EG) or a control group (CG) of usual care. Six-minute walk distance (6MWD), St George's Respiratory Questionnaire (SGRQ) and Chronic Respiratory Disease Questionnaire (CRQ) were measured at baseline, eight weeks and 26 weeks by an assessor blinded to group allocation.

Results: Thirty-three of 35 male participants completed the study. Sixty-nine percent of participants had asbestos related pleural disease. At eight weeks, compared to the CG, the EG showed a significantly increased 6MWD (mean difference (95%CI)) 53 metres (32 to 74), improved SGRQ total score, -7 points (-13 to -1) and increased CRQ total score, 6.4 points (2.1 to 10.7). At 26 weeks significant between-group differences were maintained in 6MWD, 45 metres (17 to 73) and CRQ total score, 13.1 points (5.2 to 20.9).

Conclusion: Exercise training improved short and long-term exercise capacity and HRQoL in people with dust-related pleural and interstitial respiratory diseases.

Clinical trial registration number: ANZCTR12608000147381. Date trial registered: 27.03.2008.

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Figures

Figure 1
Figure 1
Participant flow.
Figure 2
Figure 2
Change in six-minute walk distance (6MWD). Data are means and standard errors. *p < 0.05, exercise training group (EG) versus control group (CG).
See this image and copyright information in PMC

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Pre-publication history
    1. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2466/14/180/prepub

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