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. 2014;27 Suppl 1(Suppl 1):51-5.
doi: 10.1590/s0102-6720201400s100013.

Effect of the ingestion of the palm oil and glutamine in serum levels of GLP-1, PYY and glycemia in diabetes mellitus type 2 patients submitted to metabolic surgery

[Article in English, Portuguese]
Tharsus Dias Takeuti  1 , Guilherme Azevedo Terra  1 , Alex Augusto da Silva  1 , Júverson Alves Terra Jr  1 , Luci Mara da Silva  1 , Eduardo Crema  1
Affiliations

Effect of the ingestion of the palm oil and glutamine in serum levels of GLP-1, PYY and glycemia in diabetes mellitus type 2 patients submitted to metabolic surgery

[Article in English, Portuguese]
Tharsus Dias Takeuti et al. Arq Bras Cir Dig. 2014.

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] Arq Bras Cir Dig. 2017 Apr-Jun;30(2):164. doi: 10.1590/0102-6720201700020020. Arq Bras Cir Dig. 2017. PMID: 29257858 Free PMC article.

Abstract
in English, Portuguese

Background: Incretins are hormones produced by the intestine and can stimulate the secretion of insulin, helping to diminish the post-prandial glycemia. The administration of an emulsion of palm oil can help in the maintenance of the weight, and can increase circulating incretins levels. Glutamine increases the concentration of incretins in diabetic people. Both can help in metabolic syndrome.

Aim: To analyze the effects of ingestion of palm oil and glutamine in glycemia and in incretins in patients with diabetes submitted to surgical duodenojejunal exclusion with ileal interposition without gastrectomy.

Methods: Eleven diabetic type 2 patients were included and were operated. They were called to laboratory follow-up without eating anything between eight and 12 hours. They had there blood collected after the stimulus of the palm oil and glutamine taken in different days. For the hormonal doses were used ELISA kits.

Results: The glycemia showed a meaningful fall between the fast and two hours after the stimulus of the palm oil (p=0,018). With the glutamine the GLP-1 showed an increase between the fast and one hour (p=0,32), the PYY showed an important increase between the fast and one hour after the stimulus (p=0,06), the glycemia showed a meaningful fall after two hours of the administration of the stimulus (p=0,03).

Conclusion: Palm oil and glutamine can influence intestinal peptides and glucose.

Racional: A administração de óleo de palma auxilia na manutenção do peso e aumenta níveis de incretinas circulantes. A glutamina aumenta a concentração de incretinas em indivíduos diabéticos. Assim, eles podem influenciar no tratamento da síndrome metabólica.

Objetivo: Analisar os efeitos da ingestão de óleo de palma e glutamina na glicemia e incretinas em pacientes diabéticos que foram submetidos à operação de exclusão duodenojejunal com interposição ileal sem gastrectomia.

Métodos: Participaram 11 pacientes, portadores de diabete melito tipo 2, que foram operados com exclusão duodenojejunal com interposição ileal sem gastrectomia. Foram convocados para comparecer ao laboratório em jejum de oito a 12 horas e submetidos ao procedimento de coleta de sangue após os estímulos de óleo de palma e glutamina via oral em dias distintos. Para as dosagens hormonais foram utilizados kits de ELISA.

Resultados: A glicemia apresentou queda significativa entre o jejum e duas horas após o estímulo de óleo de palma (p=0,018). Com a glutamina, o GLP-1 apresentou aumento entre o jejum e uma hora (p=0,32); o PYY apresentou aumento entre o jejum e uma hora após o estímulo (p=0,06); a glicemia apresentou queda significativa após duas horas da administração do estímulo (p=0,03).

Conclusão: O óleo de palma e a glutamina podem influenciar os peptídeos intestinais e na glicemia.

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Conflict of interest statement

Conflicts of interest: none

Figures

Figure 1
Figure 1
Graph showing the median and minimum and maximum values of blood glucose levels in the fasted state and 1 h and 2 h after the administration of palm oil (nonparametric Friedman test) *p=0.018
Figure 2
Figure 2
Graph showing the median and minimum and maximum values of PYY concentration in the fasted state and 1 h and 2 h after the administration of palm oil (nonparametric Friedman test) *p=0.0002
Figure 3
Figure 3
Graph showing the median and minimum and maximum values of GLP-1 concentration in the fasted state and 1 h and 2 h after the administration of palm oil (nonparametric Friedman test) *p=0.04
Figure 4
Figure 4
Graph showing the median and minimum and maximum values of blood glucose levels in the fasted state and 1 h and 2 h after the administration of glutamine (nonparametric Friedman test) *p=0.03
Figure 5
Figure 5
Graph showing the median and minimum and maximum values of PYY in the fasted state and 1 h and 2 h after the administration of glutamine (nonparametric Friedman test) p=0.06
Figure 6
Figure 6
Graph showing the median and minimum and maximum values of GLP-1 in the fasted state and 1 h and 2 h after the administration of glutamine (nonparametric Friedman test) p=0.32
See this image and copyright information in PMC

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