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Randomized Controlled Trial
. 2014 Nov;72(11):851-5.
doi: 10.1590/0004-282x20140148.

Amitriptyline and aerobic exercise or amitriptyline alone in the treatment of chronic migraine: a randomized comparative study

Michelle Dias Santos Santiago  1 , Deusvenir de Souza Carvalho  1 , Alberto Alain Gabbai  1 , Mariana Machado Pereira Pinto  1 , Andrea Regina Correa Moutran  1 , Thais Rodrigues Villa  1
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Free article
Randomized Controlled Trial

Amitriptyline and aerobic exercise or amitriptyline alone in the treatment of chronic migraine: a randomized comparative study

Michelle Dias Santos Santiago et al. Arq Neuropsiquiatr. 2014 Nov.
Free article

Abstract

To compare the preventive treatment benefits of amitriptyline and aerobic exercise or amitriptyline alone in patients with chronic migraine.

Method: Sixty patients, both genders, aged between 18 and 50 years, with a diagnosis of chronic migraine, were randomized in groups called amitriptyline and aerobic exercise or amitriptyline alone. The following parameters were evaluated: headache frequency, intensity and duration of headache, days of the analgesic medication use, body mass index (BMI), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) scores.

Results: In the evaluated parameters, was observed decrease in headache frequency (p=0.001), moderate intensity (p=0.048), in headache duration (p=0.001), the body mass index (p=0.001), Beck Depression Inventory (p=0.001) and Beck Anxiety Inventory scores (p=0.001), when groups were compared in the end of third month.

Conclusion: In this study, the amitriptyline was an effective treatment for chronic migraine, but its efficacy was increased when combined with aerobic exercise.

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