Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Oct;40(5):528-34.
doi: 10.1590/s1806-37132014000500009.

Air stacking: effects on pulmonary function in patients with spinal muscular atrophy and in patients with congenital muscular dystrophy

[Article in English, Portuguese]
Tanyse Bahia Carvalho Marques  1 , Juliana de Carvalho Neves  1 , Leslie Andrews Portes  1 , João Marcos Salge  1 , Edmar Zanoteli  1 , Umbertina Conti Reed  1
Affiliations

Air stacking: effects on pulmonary function in patients with spinal muscular atrophy and in patients with congenital muscular dystrophy

[Article in English, Portuguese]
Tanyse Bahia Carvalho Marques et al. J Bras Pneumol. 2014 Oct.

Abstract

Objective: Respiratory complications are the main causes of morbidity and mortality in patients with neuromuscular disease (NMD). The objectives of this study were to determine the effects that routine daily home air-stacking maneuvers have on pulmonary function in patients with spinal muscular atrophy (SMA) and in patients with congenital muscular dystrophy (CMD), as well as to identify associations between spinal deformities and the effects of the maneuvers.

Methods: Eighteen NMD patients (ten with CMD and eight with SMA) were submitted to routine daily air-stacking maneuvers at home with manual resuscitators for four to six months, undergoing pulmonary function tests before and after that period. The pulmonary function tests included measurements of FVC; PEF; maximum insufflation capacity (MIC); and assisted and unassisted peak cough flow (APCF and UPCF, respectively) with insufflations.

Results: After the use of home air-stacking maneuvers, there were improvements in the APCF and UPCF. In the patients without scoliosis, there was also a significant increase in FVC. When comparing patients with and without scoliosis, the increases in APCF and UPCF were more pronounced in those without scoliosis.

Conclusions: Routine daily air-stacking maneuvers with a manual resuscitator appear to increase UPCF and APCF in patients with NMD, especially in those without scoliosis.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Correlation analysis of pre-training data. UPCF: unassisted peak cough flow; MIC: maximum insufflation capacity; APCF: assisted peak cough flow; ?APCF-UPCF: difference between APCF and UPCF; and ?MIC-FVC: difference between MIC and FVC.
Figura 1
Figura 1. Análise de correlação de dados no pré-treinamento. PFTNA: pico de fluxo da tosse não assistido; CIM: capacidade de insuflação máxima; PFTASS: pico de fluxo da tosse assistido; ?PFTASS-PFTNA: diferença entre PFTASS e PFTNA; e ?CIM-CVF: diferença entre CIM e CVF.
See this image and copyright information in PMC

References

    1. Zanoteli E, Maximino JR, Conti Reed U, Chadi G. Spinal muscular atrophy: from animal model to clinical trial. Funct Neurol. 2010;25(2):73–79. - PubMed
    1. Munsat TL, Davies KE. International SMA Consortium meeting. (26-28 June 1992, Bonn, Germany) Neuromuscul Disord. 1992;2(5-6):423–428. http://dx.doi.org/10.1016/S0960-8966(06)80015-5 - DOI - PubMed
    1. Reed UC. Congenital muscular dystrophy. Part I: a review of phenotypical and diagnostic aspects. Arq Neuropsiquiatr. 2009;67(1):144–168. http://dx.doi.org/10.1590/S0004-282X2009000100038 - DOI - PubMed
    1. Bach JR, Ishikawa Y, Kim H. Prevention of pulmonary morbidity for patients with Duchenne muscular dystrophy. Chest. 1997;112(4):1024–1028. http://dx.doi.org/10.1378/chest.112.4.1024 - DOI - PubMed
    1. Tzeng AC, Bach JR. Prevention of pulmonary morbidity for patients with neuromuscular disease. Chest. 2000;118(5):1390–1396. http://dx.doi.org/10.1378/chest.118.5.1390 - DOI - PubMed