The contributions of Sidney D. Nelson to drug metabolism research

Abstract

This article provides a review of Sid Nelson's key contributions to the fields of drug metabolism and toxicology over a long and distinguished career. Selected examples are discussed to illustrate the diversity of Sid's research, with an emphasis on understanding mechanistic aspects of metabolic activation processes and structure-toxicity relationships. These examples serve to illustrate the importance of emerging mass spectrometry and isotope labeling techniques in elucidating details of foreign compound metabolism at the molecular level, an area in which Sid pioneered most effectively.

Keywords: Acetaminophen; bioactivation; drug metabolism; reactive metabolites; toxicology.