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. 2011 Sep;12(3):233-244.
doi: 10.1016/j.cpem.2011.07.005.

Emergent Complications in the Pediatric Hematopoietic Stem Cell Transplant Patient

Ashley Munchel  1 , Allen Chen  2 , Heather Symons  2
Affiliations

Emergent Complications in the Pediatric Hematopoietic Stem Cell Transplant Patient

Ashley Munchel et al. Clin Pediatr Emerg Med. 2011 Sep.

Abstract

Hematopoietic cell transplantation is the only potentially curative option for a variety of pediatric malignant and nonmalignant disorders. Despite advances in transplantation biology and immunology as well as in posttransplant management that have contributed to improved survival and decreased transplant-related mortality, hematopoietic cell transplantation does not come without significant risk of complications. When patients who have undergone hematopoietic cell transplantation present to the emergency department, it is important to consider a variety of therapy-related complications to optimize management and outcome. In this article, we use clinical cases to highlight some of the more common emergent complications after hematopoietic cell transplantation.

Keywords: bronchiolitis obliterans; calcineurin inhibitor; congestive heart failure; diffuse alveolar hemorrhage; graft-versus-host disease; hematopoietic cell transplantation; hemorrhagic cystitis; idiopathic pulmonary syndrome; immunosuppression; infection; posterior reversible encephalopathy; thrombotic microangiopathy.

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