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Review
. 2014;1(4):242-250.
doi: 10.1007/s40473-014-0024-z.

Genome-Wide Studies of Specific Language Impairment

Rose H Reader  1 , Laura E Covill  1 , Ron Nudel  1 , Dianne F Newbury  2
Affiliations
Review

Genome-Wide Studies of Specific Language Impairment

Rose H Reader et al. Curr Behav Neurosci Rep. 2014.

Abstract

Specific language impairment (SLI) is a multifactorial neurodevelopmental disorder which occurs unexpectedly and without an obvious cause. Over a decade of research suggests that SLI is highly heritable. Several genes and loci have already been implicated in SLI through linkage and targeted association methods. Recently, genome-wide association studies (GWAS) of SLI and language traits in the general population have been reported and, consequently, new candidate genes have been identified. This review aims to summarise the literature concerning genome-wide studies of SLI. In addition, this review highlights the methodologies that have been used to research the genetics of SLI to date, and also considers the current, and future, contributions that GWAS can offer.

Keywords: Genome-Wide Association Studies (GWAS); Genome-Wide Linkage Analysis (GWLA); Neurodevelopmental Disorders; Neurogenetics; Specific Language Impairment (SLI).

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Conflict of interest statement

Dianne Newbury received a grant from the Medical Research Council. Laura Covill, Rose Reader and Ron Nudel have no conflicts of interest.

Figures

Fig. 1
Fig. 1
A diagrammatic representation of specific language impairment (SLI) linkage regions and associations
See this image and copyright information in PMC

References

    1. Tomblin JB, et al. Prevalence of specific language impairment in kindergarten children. J Speech Lang Hear Res. 1997;40(6):1245–60. doi: 10.1044/jslhr.4006.1245. - DOI - PMC - PubMed
    1. Law J, et al. Screening for primary speech and language delay: a systematic review of the literature. Int J Lang Commun Disord. 1998;33(S1):21–3. doi: 10.3109/13682829809179388. - DOI - PubMed
    1. Bishop DVM. What causes specific language impairment in children? Curr Dir Psychol Sci. 2006;15(5):217–21. doi: 10.1111/j.1467-8721.2006.00439.x. - DOI - PMC - PubMed
    1. Tomblin JB, Records NL, Zhang X. A system for the diagnosis of specific language impairment in kindergarten children. J Speech Hear Res. 1996;39(6):1284–94. doi: 10.1044/jshr.3906.1284. - DOI - PubMed
    1. SLI Consortium (SLIC) Highly significant linkage to the SLI1 locus in an expanded sample of individuals affected by specific language impairment. Am J Hum Genet. 2004;74(6):1225–38. doi: 10.1086/421529. - DOI - PMC - PubMed

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