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Review
. 2015 Jan;33(1):13-23.
doi: 10.1016/j.det.2014.09.002.

The immunopathogenesis of psoriasis

Jaehwan Kim  1 , James G Krueger  2
Affiliations
Review

The immunopathogenesis of psoriasis

Jaehwan Kim et al. Dermatol Clin. 2015 Jan.

Abstract

Psoriasis vulgaris is a chronic inflammatory skin disease that results from the complex interplay between keratinocytes, dendritic cells, and T cells. Keratinocytes trigger innate and adaptive immune responses. Dermal myeloid dendritic cells regulate T cell activation and production of cytokines and chemokines that amplify inflammation. Most of the psoriatic T cells discretely produce interferon-γ, interleukin (IL)-17, and IL-22. The initiation phase of psoriasis involves Toll-like receptors, antimicrobial peptide LL37, and plasmacytoid dendritic cells. Keratinocytes are the main cutaneous cell type expressing IL-17 receptors and hence the immune circuit is amplified by keratinocytes upregulating mRNAs for a range of inflammatory products.

Keywords: Dendritic cells; Immunology; Immunopathogenesis; Keratinocyte; Psoriasis; T cells.

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