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Case Reports
. 2015 Oct;30(5):308-10.
doi: 10.1002/jca.21371. Epub 2014 Nov 21.

Carfilzomib associated thrombotic microangiopathy initially treated with therapeutic plasma exchange

Matthew R Sullivan  1   2 , Alexey V Danilov  1   2 , Frederick Lansigan  1   2 , Nancy M Dunbar  1   3
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Case Reports

Carfilzomib associated thrombotic microangiopathy initially treated with therapeutic plasma exchange

Matthew R Sullivan et al. J Clin Apher. 2015 Oct.

Abstract

Drug associated thrombotic microangiopathy (TMA) is a rare event causing thrombocytopenia, microangiopathic anemia, renal failure, and neurologic abnormalities. Here, we present a case of TMA that occurred during the first cycle of treatment with carfilzomib for relapsed multiple myeloma.

Keywords: carfilzomib; multiple myeloma; plasma exchange; thrombotic microangiopathy.

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