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INFRAFRONTIER--providing mutant mouse resources as research tools for the international scientific community

INFRAFRONTIER Consortium. Nucleic Acids Res. 2015 Jan.

Abstract

The laboratory mouse is a key model organism to investigate mechanism and therapeutics of human disease. The number of targeted genetic mouse models of disease is growing rapidly due to high-throughput production strategies employed by the International Mouse Phenotyping Consortium (IMPC) and the development of new, more efficient genome engineering techniques such as CRISPR based systems. We have previously described the European Mouse Mutant Archive (EMMA) resource and how this international infrastructure provides archiving and distribution worldwide for mutant mouse strains. EMMA has since evolved into INFRAFRONTIER (http://www.infrafrontier.eu), the pan-European research infrastructure for the systemic phenotyping, archiving and distribution of mouse disease models. Here we describe new features including improved search for mouse strains, support for new embryonic stem cell resources, access to training materials via a comprehensive knowledgebase and the promotion of innovative analytical and diagnostic techniques.

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Figures

Figure 1.
Figure 1.
INFRAFRONTIER strain search. A simplified grid summing up available mouse strains is returned based on lexical matching. Rows are expanded when the plus icon is selected, giving summaries on a wide range of data available for a strain.
Figure 2.
Figure 2.
Online strain submission tool. An online tool guides users through a series of steps to upload data about a strain they wish to deposit in the EMMA resource. Screenshot depicts the step where genotype information is entered. The use of pull down menus reduces user errors and curation burden.
See this image and copyright information in PMC

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