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. 2014 Nov 19;19(11):19172-9.
doi: 10.3390/molecules191119172.

Anti-cholinesterase activity of lycopodium alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis

Nguyen Ngoc Chuong  1 , Nguyen Thi Thu Huong  1 , Tran Manh Hung  2 , Tran Cong Luan  3
Affiliations

Anti-cholinesterase activity of lycopodium alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis

Nguyen Ngoc Chuong et al. Molecules. .

Abstract

A series of Lycopodium alkaloids, namely lycosquarosine A (1), acetylaposerratinine (2), huperzine A (3), huperzine B (4), 8α-hydrophlemariurine B (5), and huperzinine (6), has been isolated from Vietnamese Huperzia squarrosa. Among them, lycosquarosine A (1) is the new metabolite of the natural source. Lycosquarosine A completely inhibited AChE activity in a dose dependent manner with an IC50 value of 54.3 μg/mL, while acetylaposerratinine (2) showed stronger inhibitory activity than 1 with an IC50 value of 15.2 µg/mL. This result indicates that these alkaloids may be a potent source of AChE inhibitors.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structures of isolated compounds 1–6.
Figure 2
Figure 2
Selected 2D NMR correlations of 1.
See this image and copyright information in PMC

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