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. 2014 Nov 22:14:1203.
doi: 10.1186/1471-2458-14-1203.

Systematic review and meta-analysis of the proportion of Campylobacter cases that develop chronic sequelae

Jessica Keithlin  1   2 , Jan Sargeant  3   4 , M Kate Thomas  5 , Aamir Fazil  6
Affiliations

Systematic review and meta-analysis of the proportion of Campylobacter cases that develop chronic sequelae

Jessica Keithlin et al. BMC Public Health. .

Abstract

Background: Understanding of chronic sequelae development after Campylobacter infection is limited. The objective of the study was to determine via systematic review and meta-analysis the proportion of Campylobacter cases that develop chronic sequelae.

Methods: A systematic review of English language articles published prior to July 2011 located using Pubmed, Agricola, CabDirect, and Food Safety and Technology Abstracts. Observational studies reporting the number of Campylobacter cases that developed reactive arthritis (ReA), Reiter's syndrome (RS), haemolytic uraemic syndrome (HUS), irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) ,Guillain Barré syndrome (GBS) or Miller Fisher syndrome (MFS) were included. Data extraction through independent extraction of articles by four reviewers (two per article). Random effects meta-analysis was performed and heterogeneity was assessed using the I(2) value. Meta-regression was used to explore the influence of study level variables on heterogeneity.

Results: A total of 31 studies were identified; 20 reported on ReA, 2 reported on RS, 9 reported on IBS, 3 studies reported on IBD, 8 reported on GBS, 1 reported on MFS and 3 reported on HUS. The proportion of Campylobacter cases that developed ReA was 2.86% (95% CI 1.40% - 5.61%, I(2) = 97.7%), irritable bowel syndrome was 4.01% (95% CI 1.41% - 10.88%, I(2) = 99.2%). Guillain Barré syndrome was 0.07% (95% CI 0.03% - 0.15%, I(2) = 72.7%).

Conclusions: A significant number of Campylobacter cases develop a chronic sequela. However, results should be interpreted with caution due to the high heterogeneity.

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Figures

Figure 1
Figure 1
Results from the literature search for studies relating to chronic sequelae associated with Campylobacter published prior to July 2011.
Figure 2
Figure 2
Distribution of estimates of the proportion of Campylobacter cases that develop reactive arthritis from studies published prior to July 2011.
Figure 3
Figure 3
Forest plot of the proportion of cases of reactive arthritis from studies published before July 2011.
Figure 4
Figure 4
Forest plot of the proportion of cases of Campylobacter that develop irritable bowel syndrome from studies published before July 2011.
Figure 5
Figure 5
Forest plot of the proportion of cases of Campylobacter that develop Guillain Barre syndrome from studies published before July 2011.
See this image and copyright information in PMC

References

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Pre-publication history
    1. The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2458/14/1203/prepub

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