doi: 10.1016/0006-291x(89)92499-6.
Heteroplasmy of mitochondrial genomes in clonal cultures from patients with Kearns-Sayre syndrome
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- PMID: 2541710
- DOI: 10.1016/0006-291x(89)92499-6
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Heteroplasmy of mitochondrial genomes in clonal cultures from patients with Kearns-Sayre syndrome
Biochem Biophys Res Commun.
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Abstract
We have analyzed heteroplasmy of mitochondrial DNA in clonal cultures from two patients with Kearns-Sayre syndrome, and have found that individual muscle or fibroblast clones contained either a mixed (i.e. heteroplasmic) population of normal and deleted mitochondrial DNAs, or only normal mitochondrial DNAs (i.e. homoplasmic at a level of detection of less than 1% deleted genomes). The heteroplasmic clones grew significantly more slowly than did "homoplasmic" clones, probably due to defects of respiratory chain enzymes containing mtDNA-encoded polypeptides.
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