Geroscience: linking aging to chronic disease

Affiliations

¹ Buck Institute for Research on Aging, Novato, CA USA. Electronic address: bkennedy@buckinstitute.org.
² Penn Epigenetics Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology and Department of Genetics and Department of Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
³ Department of Genetics, Stanford University, Stanford, CA 94305, USA; Glenn Center for the Biology of Aging, Stanford University, Stanford, CA 94305, USA.
⁴ Buck Institute for Research on Aging, Novato, CA USA; Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
⁵ Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
⁶ Department of Psychiatry, School of Medicine, University of California, San Francisco, CA 94143, USA.
⁷ IRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital, Bologna, Italy; C.I.G., Interdepartmental Center 'L. Galvani' for Integrated Studies on Bioinformatics, Biophysics, and Biocomplexity, University of Bologna, 3 Bologna, Italy; DIMES, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 3 Bologna, Italy.
⁸ Buck Institute for Research on Aging, Novato, CA USA.
⁹ Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA.
¹⁰ Department of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
¹¹ Glenn Center for the Biology of Aging, Stanford University, Stanford, CA 94305, USA; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Administration Palo Alto Health Care System, Palo Alto, CA 94304, USA.
¹² Donald W Reynolds Endowed Chair of Aging Research, Professor of Geriatric Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA; Oklahoma City VA Medical Center, Oklahoma City, OK 73104, USA.
¹³ Icahn School of Medicine at Mount Sinai, Department of Genetics and Genomic Sciences and the Icahn Institute for Genomics and Multiscale Biology, New York, NY 10029, USA.
¹⁴ Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Administration Palo Alto Health Care System, Palo Alto, CA 94304, USA.
¹⁵ Division of Aging Biology, National Institute on Aging, Bethesda, MD 20892, USA.

PMID: 25417146
PMCID: PMC4852871
DOI: 10.1016/j.cell.2014.10.039

Geroscience: linking aging to chronic disease

Brian K Kennedy et al. Cell. 2014.

. 2014 Nov 6;159(4):709-13.

doi: 10.1016/j.cell.2014.10.039.

Authors

Affiliations

¹ Buck Institute for Research on Aging, Novato, CA USA. Electronic address: bkennedy@buckinstitute.org.
² Penn Epigenetics Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology and Department of Genetics and Department of Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
³ Department of Genetics, Stanford University, Stanford, CA 94305, USA; Glenn Center for the Biology of Aging, Stanford University, Stanford, CA 94305, USA.
⁴ Buck Institute for Research on Aging, Novato, CA USA; Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
⁵ Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
⁶ Department of Psychiatry, School of Medicine, University of California, San Francisco, CA 94143, USA.
⁷ IRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital, Bologna, Italy; C.I.G., Interdepartmental Center 'L. Galvani' for Integrated Studies on Bioinformatics, Biophysics, and Biocomplexity, University of Bologna, 3 Bologna, Italy; DIMES, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 3 Bologna, Italy.
⁸ Buck Institute for Research on Aging, Novato, CA USA.
⁹ Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA.
¹⁰ Department of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
¹¹ Glenn Center for the Biology of Aging, Stanford University, Stanford, CA 94305, USA; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Administration Palo Alto Health Care System, Palo Alto, CA 94304, USA.
¹² Donald W Reynolds Endowed Chair of Aging Research, Professor of Geriatric Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA; Oklahoma City VA Medical Center, Oklahoma City, OK 73104, USA.
¹³ Icahn School of Medicine at Mount Sinai, Department of Genetics and Genomic Sciences and the Icahn Institute for Genomics and Multiscale Biology, New York, NY 10029, USA.
¹⁴ Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Administration Palo Alto Health Care System, Palo Alto, CA 94304, USA.
¹⁵ Division of Aging Biology, National Institute on Aging, Bethesda, MD 20892, USA.

PMID: 25417146
PMCID: PMC4852871
DOI: 10.1016/j.cell.2014.10.039

Abstract

Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches. Given that the elderly population is dramatically increasing and that aging is the greatest risk factor for a majority of chronic diseases driving both morbidity and mortality, it is critical to expand geroscience research directed at extending human healthspan.

PubMed Disclaimer

Figures

See this image and copyright information in PMC

References

1. Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM. Nature. 2011;479:232–236. - PMC - PubMed
1. Coppe JP, Patil CK, Rodier F, Sun Y, Munoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J. PLoS Biol. 2008;6:2853–2868. - PMC - PubMed
1. Deelen J, Beekman M, Capri M, Franceschi C, Slagboom PE. BioEssays : news and reviews in molecular, cellular and developmental biology. 2013;35:386–396. - PMC - PubMed
1. Harrison DE, Strong R, Allison DB, Ames BN, Astle CM, Atamna H, Fernandez E, Flurkey K, Javors MA, Nadon NL, et al. Aging Cell. 2014;13:273–282. - PMC - PubMed
1. Heintz C, Mair W. Cell. 2014;156:408–411. - PMC - PubMed

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
Medical
- ClinicalTrials.gov
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Geroscience: linking aging to chronic disease

Affiliations

Geroscience: linking aging to chronic disease

Authors

Affiliations

Abstract

Figures

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical