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. 2014 Nov 6;159(4):956-956.e1.
doi: 10.1016/j.cell.2014.10.045.

SnapShot: Mammalian Sirtuins

Kristin A Anderson  1 , Michelle F Green  2 , Frank K Huynh  2 , Gregory R Wagner  2 , Matthew D Hirschey  3
Affiliations

SnapShot: Mammalian Sirtuins

Kristin A Anderson et al. Cell. .

Abstract

The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan. The seven mammalian sirtuins, SIRT1-7, share a highly conserved NAD+-binding catalytic core domain although they exhibit distinct expression patterns, catalytic activities, and biological functions. This SnapShot provides an overview of these properties, with an emphasis on their relevance to aging.

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References

    1. Barber MF, Michishita-Kioi E, Xi Y, Tasselli L, Kioi M, Moqtaderi Z, Tennen RI, Paredes S, Young NL, Chen K, et al. Nature. 2012;487:114–118. - PMC - PubMed
    1. Cantó C, Auwerx J. Pharmacol. Rev. 2012;64:166–187. - PMC - PubMed
    1. Finkel T, Deng CX, Mostoslavsky R. Nature. 2009;460:587–591. - PMC - PubMed
    1. Gertler AA, Cohen HY. Biogerontology. 2013;14:629–639. - PubMed
    1. Jiang H, Khan S, Wang Y, Charron G, He B, Sebastian C, Du J, Kim R, Ge E, Mostoslavsky R, et al. Nature. 2013;496:110–113. - PMC - PubMed

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