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. 2014 Dec;20(12):2115-8.
doi: 10.3201/eid2012.140408.

Human metapneumovirus infection in chimpanzees, United States

Owen M Slater, Karen A Terio, Yange Zhang, Dean D Erdman, Eileen Schneider, Jane M Kuypers, Steven M Wolinsky, Kevin J Kunstman, Jennifer Kunstman, Michael J Kinsel, Kathryn C Gamble

Human metapneumovirus infection in chimpanzees, United States

Owen M Slater et al. Emerg Infect Dis. 2014 Dec.

Abstract

Zoonotic disease transmission and infections are of particular concern for humans and closely related great apes. In 2009, an outbreak of human metapneumovirus infection was associated with the death of a captive chimpanzee in Chicago, Illinois, USA. Biosecurity and surveillance for this virus in captive great ape populations should be considered.

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Figures

Figure 1
Figure 1
Percentage of human metapneumovirus (HMPV)–positive test results, by week of report, National Respiratory and Enteric Virus Surveillance System, United States, July 2008–January 2013.
Figure 2
Figure 2
A) Bronchiolar epithelium of chimpanzees infected with human metapneumovirus, United States, 2009, showing cell variation from attenuated to piled and disorganized. Epithelial cells lack cilia, and lumens contain foamy macrophages, neutrophils, and hemorrhage. Adjacent air spaces are filled with similar inflammatory cells. Scale bar = 70 μm. B) Alveoli lined with plump type II pneumocytes and fibrin. Inset: Rare, deeply basophilic, smudged nuclei are present in some areas. Scale bar = 20 μm. Hematoxylin and eosin stain.
See this image and copyright information in PMC

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