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. 2014 Dec;15(12):1203-14.
doi: 10.1016/j.jpain.2014.09.004. Epub 2014 Oct 29.

A pain research agenda for the 21st century

Robert W Gereau 4th  1 , Kathleen A Sluka  2 , William Maixner  3 , Seddon R Savage  4 , Theodore J Price  5 , Beth B Murinson  6 , Mark D Sullivan  7 , Roger B Fillingim  8
Affiliations

A pain research agenda for the 21st century

Robert W Gereau 4th et al. J Pain. 2014 Dec.

Abstract

Chronic pain represents an immense clinical problem. With tens of millions of people in the United States alone suffering from the burden of debilitating chronic pain, there is a moral obligation to reduce this burden by improving the understanding of pain and treatment mechanisms, developing new therapies, optimizing and testing existing therapies, and improving access to evidence-based pain care. Here, we present a goal-oriented research agenda describing the American Pain Society's vision for pain research aimed at tackling the most pressing issues in the field.

Perspective: This article presents the American Pain Society's view of some of the most important research questions that need to be addressed to advance pain science and to improve care of patients with chronic pain.

Keywords: Chronic pain; pain education; pain research; pain treatment; research funding.

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Conflict of interest statement

All other authors declare no relevant conflicts of interest.

Figures

Figure 1
Figure 1
Expenditures for 6 major chronic conditions. Societal cost data (black bars) were derived from the following sources: chronic pain, heart disease, cancer, diabetes, HIV/AIDS, and Alzheimer’s disease. All societal costs were converted to 2010 dollars. NIH expenditures (gray bars) are from the NIH categorical spending data providedonnih.gov for 2012, the most recent year available.
See this image and copyright information in PMC

References

    1. Americans talk about pain. Available at: https://www.researchamerica.org/uploads/poll2003pain.pdf.
    1. Anand U, Facer P, Yiangou Y, Sinisi M, Fox M, McCarthy T, Bountra C, Korchev YE, Anand P. Angiotensin II type 2 receptor (AT2 R) localization and antagonist-mediated inhibition of capsaicin responses and neurite outgrowth in human and rat sensory neurons. Eur J Pain. 2013;17:1012–1026. - PMC - PubMed
    1. Anderson KO, Green CR, Payne R. Racial and ethnic disparities in pain: Causes and consequences of unequal care. J Pain. 2009;10:1187–1204. - PubMed
    1. Anttila V, Winsvold BS, Gormley P, Kurth T, Bettella F, McMahon G, Kallela M, Malik R, de Vries B, Terwindt G, Medland SE, Todt U, McArdle WL, Quaye L, Koiranen M, Ikram MA, Lehtimaki T, Stam AH, Ligthart L, Wedenoja J, Dunham I, Neale BM, Palta P, Hamalainen E, Schurks M, Rose LM, Buring JE, Ridker PM, Steinberg S, Stefansson H, Jakobsson F, Lawlor DA, Evans DM, Ring SM, Farkkila M, Artto V, Kaunisto MA, Freilinger T, Schoenen J, Frants RR, Pelzer N, Weller CM, Zielman R, Heath AC, Madden PA, Montgomery GW, Martin NG, Borck G, Gobel H, Heinze A, Heinze-Kuhn K, Williams FM, Hartikainen AL, Pouta A, van den Ende J, Uitterlinden AG, Hofman A, Amin N, Hottenga JJ, Vink JM, Heikkila K, Alexander M, Muller-Myhsok B, Schreiber S, Meitinger T, Wichmann HE, Aromaa A, Eriksson JG, Traynor BJ, Trabzuni D, North American Brain Expression Consortium, UK Brain Expression Consortium. Rossin E, Lage K, Jacobs SB, Gibbs JR, Birney E, Kaprio J, Penninx BW, Boomsma DI, van Duijn C, Raitakari O, Jarvelin MR, Zwart JA, Cherkas L, Strachan DP, Kubisch C, Ferrari MD, van den Maagdenberg AM, Dichgans M, Wessman M, Smith GD, Stefansson K, Daly MJ, Nyholt DR, Chasman DI, Palotie A North American Brain Expresssion Consortium; UK Brain Expression Consortium. International Headache Genetics Consortium: Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nat Genet. 2013;45:912–917. - PMC - PubMed
    1. Baron R, Forster M, Binder A. Subgrouping of patients with neuropathic pain according to pain-related sensory abnormalities: A first step to a stratified treatment approach. Lancet Neurol. 2012;11:999–1005. - PubMed

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