Management of diabetes in the elderly with canagliflozin: A newer hypoglycemic drug on the horizon
- PMID: 25422561
- PMCID: PMC4231550
- DOI: 10.4103/0976-500X.142428
Management of diabetes in the elderly with canagliflozin: A newer hypoglycemic drug on the horizon
Erratum in
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Erratum: Management of diabetes in the elderly with canagliflozin: A newer hypoglycemic drug on the horizon: Erratum.J Pharmacol Pharmacother. 2015 Jan-Mar;6(1):58. doi: 10.4103/0976-500X.149153. J Pharmacol Pharmacother. 2015. PMID: 25707944 Free PMC article.
Abstract
Canagliflozin is the first available oral inhibitor of sodium/glucose cotransporter 2 (SGLT2) in the market. At the outset it sounds excellent for the use in the elderly diabetic population, because of its minimal tendency to cause hypoglycemia. However, the clinician needs to exercise caution as it needs to be dosed renally. The clinician needs to be circumspect about potential drug interactions, especially when there is an underlying chronic kidney disease (CKD) and congestive heart failure (CHF). Also its use is best avoided in people who are predisposed to genital mycotic and urinary tract infections (UTI).
Keywords: Chronic kidney disease; congestive heart failure; diabetes mellitus type 2; drug interactions; elderly.
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References
-
- Zarowitz BJ. Management of diabetes mellitus in older persons. Geriatr Nurs. 2006;27:77–82. - PubMed
-
- Liao EP. Patterns of medication initiation in newly diagnosed diabetes mellitus: Quality and cost implications. Am J Med. 2012;125:S1–2. - PubMed
-
- Sehgal V, Bajwa SJ, Khaira U, Sehgal R, Bajaj A. Challenging aspects of and solutions to diagnosis, prevention, and management of hypoglycemia in critically ill geriatric patients. J Sci Soc. 2013;40:128–34.
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