Propofol alternatives in gastrointestinal endoscopy anesthesia
- PMID: 25422614
- PMCID: PMC4236943
- DOI: 10.4103/1658-354X.140893
Propofol alternatives in gastrointestinal endoscopy anesthesia
Abstract
Although propofol has been the backbone for sedation in gastrointestinal endoscopy, both anesthesiologists and endoscopists are faced with situations where an alternative is needed. Recent national shortages forced many physicians to explore these options. A midazolam and fentanyl combination is the mainstay in this area. However, there are other options. The aim of this review is to explore these options. The future would be, invariably, to move away from propofol. The reason is not in any way related to the drawbacks of propofol as a sedative. The mandate that requires an anesthesia provider to administer propofol has been a setback in many countries. New sedative drugs like Remimazolam might fill this void in the future. In the meantime, it is important to keep an open eye to the existing alternatives.
Keywords: GI endoscopy sedation; non-anesthetist administered propofol; propofol Remimazolam; propofol complications in sedation.
Conflict of interest statement
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References
-
- Riphaus A, Macias-Gomez C, Devière J, Dumonceau JM. Propofol, the preferred sedation for screening colonoscopy, is underused. Results of an international survey. Dig Liver Dis. 2012;44:389–92. - PubMed
-
- Baombe JP, Parvez K. Towards evidence-based emergency medicine: Best BETs from the Manchester Royal Infirmary. BET 1: Is propofol safe in patients with egg anaphylaxis? Emerg Med J. 2013;30:79–80. - PubMed
-
- Garnock-Jones KP, Scott LJ. Fospropofol. Drugs. 2010;70:469–77. - PubMed
-
- Cohen LB, Wecsler JS, Gaetano JN, Benson AA, Miller KM, Durkalski V, et al. Endoscopic sedation in the United States: Results from a nationwide survey. Am J Gastroenterol. 2006;101:967–74. - PubMed
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