doi: 10.1002/adma.201404256.
Epub 2014 Nov 25.
Large-pore ultrasmall mesoporous organosilica nanoparticles: micelle/precursor co-templating assembly and nuclear-targeted gene delivery
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- PMID: 25423915
- DOI: 10.1002/adma.201404256
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Large-pore ultrasmall mesoporous organosilica nanoparticles: micelle/precursor co-templating assembly and nuclear-targeted gene delivery
Adv Mater.
.
Abstract
A novel micelle/precursor co-templating assembly strategy is successfully developed to synthesize large-pore ultrasmall mesoporous organosilica nanoparticles (MONs). Furthermore, elaborately designed MONs with a cell-penetrating peptide (TAT) (MONs-PTAT) are constructed for highly efficient intranuclear gene delivery. They exhibit a high loading capacity, improved protection for the loaded gene, and enhanced transfection efficiencies of EGFP plasmid (pEGFP).
Keywords: gene delivery; large mesopores; mesoporous organosilicas; nuclear-targeted.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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