Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2014;10(8):2433-7.
doi: 10.4161/hv.29403.

Safety and Immunogenicity of purified chick embryo cell rabies vaccine (VaxiRab N) administered intradermally as post exposure prophylaxis

Hardanahalli S Ravish  1 , Veena Vijayashankar, Shampur N Madhusudana, Mysore K Sudarshan, Doddabele Ha Narayana, Gangaboraiah Andanaiah, Belludi Y Ashwin, Annadani R Rachana, Manjula Shamanna
Affiliations
Clinical Trial

Safety and Immunogenicity of purified chick embryo cell rabies vaccine (VaxiRab N) administered intradermally as post exposure prophylaxis

Hardanahalli S Ravish et al. Hum Vaccin Immunother. 2014.

Abstract

The affordability to rabies vaccine for intramuscular administration in post exposure prophylaxis is a major constraint. Therefore, in countries, where there are financial constraints, World Health Organization recommends intradermal rabies vaccination that reduces the quantity and cost of vaccination. This study was done to evaluate the safety and immunogenicity of indigenously developed rabies vaccine (VaxiRab N) in comparison to a WHO recommended rabies vaccine (Rabipur) with demonstrated efficacy when administered by intradermal route using updated Thai Red Cross regimen. Eighty-six dog bite cases were randomly given either VaxiRab N (n = 43) or Rabipur (n = 43) as post exposure prophylaxis. The rabies virus neutralizing antibody concentrations on days 14, 28, 90, and 180 were tested by modified rapid fluorescent focus inhibition test. The geometric mean RVNA concentration of both the groups were compared using t- test and was found that, P value > 0.05 on all days, thus showing no significant difference between the 2 groups. The adverse drug events were also compared using Z-test and was found to be not statistically significant (Z = 1.476, P = 0.139). In conclusion, VaxiRab N was found to be safe and effective in post exposure prophylaxis by intradermal route and was similar to the WHO recommended rabies vaccine (Rabipur) of demonstrated efficacy.

Keywords: intradermal vaccination; post exposure rabies prophylaxis; purified chick embryo cell vaccine; rabies; rabies vaccines.

PubMed Disclaimer

References

    1. World Health Organization. . Rabies vaccines: WHO position paper, Weekly Epidemiological Record, No. 32. 2010; 85:309 - 20
    1. World Health Organization. WHO expert consultation on rabies. Technical report series 982. WHO Geneva, 2013.
    1. World Health Organization. WHO expert consultation on rabies. TRS 931. WHO Geneva 2005. - PubMed
    1. Sudarshan MK, Madhusudana SN, Mahendra BJ, Rao NS, Ashwath Narayana DH, Abdul Rahman S, Meslin F-, Lobo D, Ravikumar K, Gangaboraiah. . Assessing the burden of human rabies in India: results of a national multi-center epidemiological survey. Int J Infect Dis 2007; 11:29 - 35; http://dx.doi.org/10.1016/j.ijid.2005.10.007; PMID: 16678463 - DOI - PubMed
    1. Sudarshan MK, Mahendra BJ, Madhusudana SN, Ashwoath Narayana DH, Rahman A, Rao NS, X-Meslin F, Lobo D, Ravikumar K, Gangaboraiah. . An epidemiological study of animal bites in India: results of a WHO sponsored national multi-centric rabies survey. J Commun Dis 2006; 38:32 - 9; PMID: 17370688 - PubMed

Publication types

MeSH terms

LinkOut - more resources