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. 2014 Dec;5(2):355-66.
doi: 10.1007/s13300-014-0089-4. Epub 2014 Nov 26.

Sodium Glucose Co-Transporter-2 (SGLT2) Inhibitors: A Review of Their Basic and Clinical Pharmacology

Sanjay Kalra  1
Affiliations

Sodium Glucose Co-Transporter-2 (SGLT2) Inhibitors: A Review of Their Basic and Clinical Pharmacology

Sanjay Kalra. Diabetes Ther. 2014 Dec.

Erratum in

Abstract

Sodium-glucose co-transporter-2 (SGLT2) inhibitors are a newly developed class of oral anti-diabetic drugs (OADs) with a unique mechanism of action. This review describes the biochemistry and physiology underlying the use of SGLT2 inhibitors, and their clinical pharmacology, including mechanism of action and posology. The pragmatic placement of these molecules in the existing OAD arena is also discussed.

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References

    1. Abdul GM, DeFronzo R. Dapagliflozin for the treatment of type 2 diabetes. Expert Opin Pharmacother. 2013;14:1695–1703. doi: 10.1517/14656566.2013.812632. - DOI - PMC - PubMed
    1. Bailey CJ. Renal glucose reabsorption inhibitors to treat diabetes. Trends Pharmacol Sci. 2011;32:63–71. doi: 10.1016/j.tips.2010.11.011. - DOI - PubMed
    1. Ehrenkranz J, Lewis N, Ronald KC, Roth J. Phlorizin: a review. Diabetes Metab Res Rev. 2005;21:31–38. doi: 10.1002/dmrr.532. - DOI - PubMed
    1. Wright EM. Renal Na+-glucose cotransporters. Am J Physiol Renal Physiol. 2001;280(1):F10–F18. - PubMed
    1. Lee YJ, Lee YJ, Han HJ. Regulatory mechanisms of Na(+)/glucose cotransporters in renal proximal tubule cells. Kidney Int Suppl. 2007;(106):S27–35. - PubMed

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