Randomized Controlled Trial

. 2014 Dec;33(12):2187-92.

doi: 10.7863/ultra.33.12.2187.

Accuracy of sonographic chorionicity classification in twin gestations

Yair J Blumenfeld¹, Valerija Momirova², Dwight J Rouse², Steve N Caritis², Anthony Sciscione², Alan M Peaceman², Uma M Reddy², Michael W Varner², Fergal D Malone², Jay D Iams², Brian M Mercer², John M Thorp Jr², Yoram Sorokin², Marshall W Carpenter², Julie Lo², Susan M Ramin², Margaret Harper; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network

Collaborators, Affiliations

Collaborators

Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network:
E Thom, A Braga, E Cardenas, L Leuchtenburg, W Andrews, J Sheppard, E Daugherty, M Cotroneo, H Simhan, M Hoffman, S Wilson, C Tocci, M Lake, M Talucci, M Dinsmoor, G Mallett, P Simon, M Huntley, M Ramos, C Spong, S Tolivaisa, K Anderson, F Porter, A Guzman, K Jolley, S Quinn, R Berkowitz, S South, L Paley, S Bousleiman, V Carmona, F Johnson, C Latimer, C Milluzzi, C Heggie, H Ehrenberg, B Stetzer, A Merlino, K Boggess, K Dorman, S Timlin, G Norman, C Sudz, S Blackwell, D Allard, K Leveno, L Moseley, D Soebbing-Cross, J Martinez, B Glenn-Cole, L Gilstrap, P Meis, M Swain, K Johnson, K Lanier, C Leftwich, G Anderson

Affiliations

¹ Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California USA (Y.J.B.); George Washington University Biostatistics Center, Washington, DC USA (V.M.); Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama USA (D.J.R.); University of Pittsburgh, Pittsburgh, Pennsylvania USA (S.N.C.); Drexel University, Philadelphia, Pennsylvania USA (A.C.S.); Northwestern University, Chicago, Illinois USA (A.M.P.); Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland USA (U.M.R.); University of Utah, Salt Lake City, Utah USA (M.W.V); Columbia University, New York, New York USA (F.D.M.); The Ohio State University, Columbus, Ohio USA (J.D.I); Case Western Reserve University-MetroHealth Medical Center, Cleveland, Ohio USA (B.M.M); University of North Carolina, Chapel Hill, North Carolina USA (J.M.T.); Wayne State University, Detroit, Michigan USA (Y.S); Brown University, Providence, Rhode Island USA (M.W.C.); University of Texas Southwestern Medical Center, Dallas, Texas USA (J.L); University of Texas Health Science Center, Houston, Texas USA (S.M.R.); and Wake Forest University Health Sciences, Winston-Salem, North Carolina USA (M.H.). yairb@stanford.edu.
² Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California USA (Y.J.B.); George Washington University Biostatistics Center, Washington, DC USA (V.M.); Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama USA (D.J.R.); University of Pittsburgh, Pittsburgh, Pennsylvania USA (S.N.C.); Drexel University, Philadelphia, Pennsylvania USA (A.C.S.); Northwestern University, Chicago, Illinois USA (A.M.P.); Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland USA (U.M.R.); University of Utah, Salt Lake City, Utah USA (M.W.V); Columbia University, New York, New York USA (F.D.M.); The Ohio State University, Columbus, Ohio USA (J.D.I); Case Western Reserve University-MetroHealth Medical Center, Cleveland, Ohio USA (B.M.M); University of North Carolina, Chapel Hill, North Carolina USA (J.M.T.); Wayne State University, Detroit, Michigan USA (Y.S); Brown University, Providence, Rhode Island USA (M.W.C.); University of Texas Southwestern Medical Center, Dallas, Texas USA (J.L); University of Texas Health Science Center, Houston, Texas USA (S.M.R.); and Wake Forest University Health Sciences, Winston-Salem, North Carolina USA (M.H.).

PMID: 25425377
PMCID: PMC4246197
DOI: 10.7863/ultra.33.12.2187

Randomized Controlled Trial

Accuracy of sonographic chorionicity classification in twin gestations

Yair J Blumenfeld et al. J Ultrasound Med. 2014 Dec.

. 2014 Dec;33(12):2187-92.

doi: 10.7863/ultra.33.12.2187.

Authors

Collaborators

Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network:
E Thom, A Braga, E Cardenas, L Leuchtenburg, W Andrews, J Sheppard, E Daugherty, M Cotroneo, H Simhan, M Hoffman, S Wilson, C Tocci, M Lake, M Talucci, M Dinsmoor, G Mallett, P Simon, M Huntley, M Ramos, C Spong, S Tolivaisa, K Anderson, F Porter, A Guzman, K Jolley, S Quinn, R Berkowitz, S South, L Paley, S Bousleiman, V Carmona, F Johnson, C Latimer, C Milluzzi, C Heggie, H Ehrenberg, B Stetzer, A Merlino, K Boggess, K Dorman, S Timlin, G Norman, C Sudz, S Blackwell, D Allard, K Leveno, L Moseley, D Soebbing-Cross, J Martinez, B Glenn-Cole, L Gilstrap, P Meis, M Swain, K Johnson, K Lanier, C Leftwich, G Anderson

Affiliations

¹ Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California USA (Y.J.B.); George Washington University Biostatistics Center, Washington, DC USA (V.M.); Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama USA (D.J.R.); University of Pittsburgh, Pittsburgh, Pennsylvania USA (S.N.C.); Drexel University, Philadelphia, Pennsylvania USA (A.C.S.); Northwestern University, Chicago, Illinois USA (A.M.P.); Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland USA (U.M.R.); University of Utah, Salt Lake City, Utah USA (M.W.V); Columbia University, New York, New York USA (F.D.M.); The Ohio State University, Columbus, Ohio USA (J.D.I); Case Western Reserve University-MetroHealth Medical Center, Cleveland, Ohio USA (B.M.M); University of North Carolina, Chapel Hill, North Carolina USA (J.M.T.); Wayne State University, Detroit, Michigan USA (Y.S); Brown University, Providence, Rhode Island USA (M.W.C.); University of Texas Southwestern Medical Center, Dallas, Texas USA (J.L); University of Texas Health Science Center, Houston, Texas USA (S.M.R.); and Wake Forest University Health Sciences, Winston-Salem, North Carolina USA (M.H.). yairb@stanford.edu.
² Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California USA (Y.J.B.); George Washington University Biostatistics Center, Washington, DC USA (V.M.); Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama USA (D.J.R.); University of Pittsburgh, Pittsburgh, Pennsylvania USA (S.N.C.); Drexel University, Philadelphia, Pennsylvania USA (A.C.S.); Northwestern University, Chicago, Illinois USA (A.M.P.); Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland USA (U.M.R.); University of Utah, Salt Lake City, Utah USA (M.W.V); Columbia University, New York, New York USA (F.D.M.); The Ohio State University, Columbus, Ohio USA (J.D.I); Case Western Reserve University-MetroHealth Medical Center, Cleveland, Ohio USA (B.M.M); University of North Carolina, Chapel Hill, North Carolina USA (J.M.T.); Wayne State University, Detroit, Michigan USA (Y.S); Brown University, Providence, Rhode Island USA (M.W.C.); University of Texas Southwestern Medical Center, Dallas, Texas USA (J.L); University of Texas Health Science Center, Houston, Texas USA (S.M.R.); and Wake Forest University Health Sciences, Winston-Salem, North Carolina USA (M.H.).

PMID: 25425377
PMCID: PMC4246197
DOI: 10.7863/ultra.33.12.2187

Abstract

Objectives: To evaluate the accuracy of sonographic classification of chorionicity in a large cohort of twins and investigate which factors may be associated with sonographic accuracy.

Methods: We conducted a secondary analysis of a randomized trial of preterm birth prevention in twins. Sonographic classification of chorionicity was compared with pathologic examination of the placenta. Maternal (age, body mass index, diabetes, and hypertension), obstetric (prior cesarean delivery, gestational age at the first sonographic examination, and antepartum bleeding), and sonographic (oligohydramnios, polyhydramnios, and twin-twin transfusion syndrome) factors were assessed for their possible association with accuracy.

Results: A total of 545 twin sets in which chorionicity was classified by sonography before 20 weeks' gestation were included; 455 were dichorionic and 90 were monochorionic based on pathologic examination. Sonography misclassified 35 of 545 twin pregnancies (6.4%): 18 of 455 dichorionic twins (4.0%) and 17 of 90 monochorionic twins (19.0%). The sensitivity and specificity of sonographic diagnosis of monochorionicity were 81.1% and 96.0%, respectively. In a multivariable analysis, pregnancies with initial sonographic examinations before 14 weeks' gestation were less likely to have misclassified chorionicity than those with sonographic examinations at 15 to 20 weeks (odds ratio [OR], 0.47; 95% confidence interval [CI], 0.23-0.96). For each week increase in gestational age, the odds of misclassification rose by 10% (OR, 1.10; 95% CI, 1.01-1.2). In the multivariable analysis, maternal age, body mass index, parity, and prior cesarean delivery were not associated with sonographic accuracy.

Conclusions: Sonography before 20 weeks incorrectly classified chorionicity in 6.4% of twin gestations. Those with first sonographic examinations performed at earlier gestational ages had improved chorionicity diagnosis.

Trial registration: ClinicalTrials.gov NCT00099164.

Keywords: accuracy; chorionicity; obstetric ultrasound; sonography; twins.

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Figures

**Figure 1**
Flowchart of available patients and those included in the analysis.

See this image and copyright information in PMC

References

1. National Center for Health Statistics. Births: 2009. Centers for Disease Control and Prevention website; 2010. National vital statistics reports. http://www.cdc.gov/nchs/births.
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Accuracy of sonographic chorionicity classification in twin gestations

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Accuracy of sonographic chorionicity classification in twin gestations

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