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Review
. 2015 Jan;21(1):3-10.
doi: 10.1093/molehr/gau082. Epub 2014 Nov 24.

Mitochondrial replacement: from basic research to assisted reproductive technology portfolio tool-technicalities and possible risks

Lynsey Cree  1 , Pasqualino Loi  2
Affiliations
Review

Mitochondrial replacement: from basic research to assisted reproductive technology portfolio tool-technicalities and possible risks

Lynsey Cree et al. Mol Hum Reprod. 2015 Jan.

Abstract

Mitochondrial DNA (mtDNA) mutations are a relatively common cause of progressive disorders that can be severe or even life-threatening. There is currently no cure for these disorders; therefore recent research has been focused on attempting to prevent the transmission of these maternally inherited mutations. Here we highlight the challenges of understanding the transmission of mtDNA diseases, discuss current genetic management options and explore the use of germ-line reconstruction technologies to prevent mtDNA diseases. In particular we discuss their potential, indications, limitations and possible safety concerns.

Keywords: PGD; cytoplasmic transfer; mitochondrial DNA; mitochondrial disease; nuclear transfer.

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