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. 2014 Oct;30(4):550-4.
doi: 10.4103/0970-9185.142857.

Comparison between propofol and dexmedetomidine on depth of anesthesia: A prospective randomized trial

Uddalak Chattopadhyay  1 , Suchismita Mallik  1 , Sarmila Ghosh  1 , Susmita Bhattacharya  1 , Subrata Bisai  1 , Hirak Biswas  1
Affiliations

Comparison between propofol and dexmedetomidine on depth of anesthesia: A prospective randomized trial

Uddalak Chattopadhyay et al. J Anaesthesiol Clin Pharmacol. 2014 Oct.

Abstract

Background and aims: Intravenous agents such as propofol are commonly used to maintain adequate depth of anesthesia. Dexmedetomidine which has an anesthetic sparing effect is being considered for maintaining intraoperative depth of anesthesia. We hypothesized to compare the effect of dexmedetomidine on depth of anesthesia with propofol and evaluated whether dexmedetomidine can be used as sole anesthetic agent in maintaining depth of anesthesia.

Materials and methods: Sixty patients of ASA PS I, 18-65 years of age, scheduled for laparotomy under general anesthesia were randomly divided into two groups of 30 each. Group A received propofol 1 mg/kg bolus followed by infusion (50 mcg/kg/min) and Group B received dexmedetomidine 1 mcg/kg bolus followed by infusion (0.5 mcg/kg/h). Both the groups were administered standard general anesthesia with routine monitoring along with Bispectral index (BIS) and values were recorded at intervals of 10 min. In all patients Ramsay sedation score was recorded after extubation and they were assessed for recall of intraoperative events using Modified Brice questionnaire.

Results: Heart rate and mean arterial pressure were less in Group B than Group A. Intraoperative BIS values were significantly lower in Group B (P < 0.0001). Although sedation score was more in Group B it did not prolong recovery. No recall was found in any patient.

Conclusion: Dexmedetomidine was comparable with propofol in maintaining anesthesia and it can produce better control of hemodynamics and BIS value. Thus dexmedetomidine can be used as the sole maintenance anesthetic agent.

Keywords: BIS; Bispectral index; dexmedetomidine; propofol; recall; sedation score.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Demographic data of two groups
Figure 2
Figure 2
Trend of mean arterial pressure in two groups
Figure 3
Figure 3
Trend of heart rate in two groups
Figure 4
Figure 4
Trend of bispectral index in the two groups
Figure 5
Figure 5
Sedation score of both groups
See this image and copyright information in PMC

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