Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Sep;18(5):601-7.
doi: 10.4103/0972-124X.142454.

A clinical and radiological evaluation of the relative efficacy of demineralized freeze-dried bone allograft versus anorganic bovine bone xenograft in the treatment of human infrabony periodontal defects: A 6 months follow-up study

Vikram Blaggana  1 , Amarjit Singh Gill  2 , Anshu Blaggana  3
Affiliations

A clinical and radiological evaluation of the relative efficacy of demineralized freeze-dried bone allograft versus anorganic bovine bone xenograft in the treatment of human infrabony periodontal defects: A 6 months follow-up study

Vikram Blaggana et al. J Indian Soc Periodontol. 2014 Sep.

Abstract

Background: The ultimate goal of periodontal therapy entails regeneration of the periodontal tissues lost as a consequence of periodontitis. Predictable correction of vertical osseous defects has however posed as a constant therapeutic challenge. The aim of our present study is to evaluate the relative efficacy of demineralized freeze-dried bone allograft (DFDBA) vs anorganic bovine bone xenograft (ABBX) in the treatment of human infrabony periodontal defects.

Materials and methods: 15 patients with 30 bilaterally symmetrical defect sites in either of the arches, in the age group of 25-50 years were selected as part of split-mouth study design. Defect-A (right side) was grafted with DFDBA while Defect-B (left side) was grafted with ABBX. Various clinical and radiographic parameters viz. probing depth(PD), clinical attachment level(CAL) and linear bone fill were recorded preoperatively, 12- & 24-weeks postoperatively.

Results: Both defect-A & defect-B sites exhibited a highly significant reduction in probing depth, and gain in clinical attachment level and linear bone fill at 12-weeks & at the end of 24-weeks. Comparative evaluation between the study groups revealed a statistically non-significant reduction in probing depth (P<0.1) and mean gain in linear bone fill (P<0.1). However, there was a statistically significant gain in clinical attachment level (P<0.05) in Defect-A (CD=0.356) as compared to Defect-B (CD=0.346).

Conclusions: Within the limits of this study, both the materials viz. ABBX and DFDBA are beneficial for the treatment of periodontal infrabony defects. Both the materials were found to be equally effective in all respects except the gain in attachment level, which was found to be more with DFDBA. Long-term studies are suggested to evaluate further the relative efficacy of the two grafts.

Keywords: Anorganic bovine bone xenograft; bone grafts; demineralized freeze-dried bone allograft; infrabony defects; regeneration.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Regenerative bone graft materials employed
Figure 2
Figure 2
(a) Radiographic comparison of osseous defect fill at DFDBA site at Baseline, (b) 12 weeks post-operative, (c) 24 weeks post-operative
Figure 3
Figure 3
(a) Radiographic comparison of osseous defect fill at ABBX site at Baseline (b) 12 weeks post-operative (c) 24 weeks post-operative
Figure 4
Figure 4
Crevicular incision at the surgical site (Defect-A)
Figure 5
Figure 5
Crevicular incision at the contra-lateral surgical site (Defect-B)
Figure 6
Figure 6
Osseous defect subsequent to debridement (Defect-A)
Figure 7
Figure 7
Osseous defect subsequent to debridement (Defect-B)
Figure 8
Figure 8
Following the placement of demineralized freeze-dried bone allograft
Figure 9
Figure 9
Following the placement of anorganic bovine bone xenograft
Figure 10
Figure 10
Surgical site after suturing (Defect-A)
Figure 11
Figure 11
Surgical site after suturing (Defect-B)
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Ripamonti U, Reddi AH. Periodontal regeneration: Potential role of bone morphogenetic proteins. J Periodontal Res. 1994;29:225–35. - PubMed
    1. Bowen JA, Mellonig JT, Gray JL, Towle HT. Comparison of decalcified freeze-dried bone allograft and porous particulate hydroxyapatite in human periodontal osseous defects. J Periodontol. 1989;60:647–54. - PubMed
    1. Spector M. Anorganic bovine bone and ceramic analogs of bone mineral as implants to facilitate bone regeneration. Clin Plast Surg. 1994;21:437–44. - PubMed
    1. Quintero G, Mellonig JT, Gambill VM, Pelleu GB., Jr A six-month clinical evaluation of decalcified freeze-dried bone allografts in periodontal osseous defects. J Periodontol. 1982;53:726–30. - PubMed
    1. Cortellini P, Pini Prato G, Tonetti MS. Periodontal regeneration of human infrabony defects. II. Re-entry procedures and bone measures. J Periodontol. 1993;64:261–8. - PubMed