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Review
. 2014 Nov 26;6(5):637-43.
doi: 10.4252/wjsc.v6.i5.637.

Impact of parathyroid hormone on bone marrow-derived stem cell mobilization and migration

Bruno C Huber  1 , Ulrich Grabmaier  1 , Stefan Brunner  1
Affiliations
Review

Impact of parathyroid hormone on bone marrow-derived stem cell mobilization and migration

Bruno C Huber et al. World J Stem Cells. .

Abstract

Parathyroid hormone (PTH) is well-known as the principal regulator of calcium homeostasis in the human body and controls bone metabolism via actions on the survival and activation of osteoblasts. The intermittent administration of PTH has been shown to stimulate bone production in mice and men and therefore PTH administration has been recently approved for the treatment of osteoporosis. Besides to its physiological role in bone remodelling PTH has been demonstrated to influence and expand the bone marrow stem cell niche where hematopoietic stem cells, capable of both self-renewal and differentiation, reside. Moreover, intermittent PTH treatment is capable to induce mobilization of progenitor cells from the bone marrow into the bloodstream. This novel function of PTH on modulating the activity of the stem cell niche in the bone marrow as well as on mobilization and regeneration of bone marrow-derived stem cells offers new therapeutic options in bone marrow and stem cell transplantation as well as in the field of ischemic disorders.

Keywords: Bone marrow; Migration; Mobilization; Parathyroid hormone; Stem cells.

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Figures

Figure 1
Figure 1
Impact of parathyroid hormone on mobilization and homing of bone marrow-derived stem cells. Left axis: PTH administration results in mobilization of BMCs from bone marrow into peripheral blood via endogenous release of G-CSF. Right axis: PTH results in down-regulation of DPPIV, which inhibits inactivation of SDF-1 and therefore promotes homing of CXCR4+ BMCs. PTH: Parathyroid hormone; BMCs: Bone marrow-derived stem cells; G-CSF: Granulocyte colony-stimulating factor; SDF-1: Stromal de-rived factor-1.
See this image and copyright information in PMC

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