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Review
. 2014;6(10):1097-112.
doi: 10.2217/imt.14.72.

Cytokine production associated with smallpox vaccine responses

Whitney L Simon  1 , Hannah M Salk, Inna G Ovsyannikova, Richard B Kennedy, Gregory A Poland
Affiliations
Review

Cytokine production associated with smallpox vaccine responses

Whitney L Simon et al. Immunotherapy. 2014.

Abstract

Smallpox was eradicated 34 years ago due to the success of the smallpox vaccine; yet, the vaccine continues to be studied because of its importance in responding to potential biological warfare and the adverse events associated with current smallpox vaccines. Interindividual variations in vaccine response are observed and are, in part, due to genetic variation. In some cases, these varying responses lead to adverse events, which occur at a relatively high rate for the smallpox vaccine compared with other vaccines. Here, we aim to summarize the cytokine responses associated with smallpox vaccine response to date. Along with a description of each of these cytokines, we describe the genetic and adverse event data associated with cytokine responses to smallpox vaccination.

Keywords: cellular immunity; cytokines; humoral immunity; smallpox vaccine; vaccines; vaccinia virus.

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Figures

Figure 1
Figure 1. Interactions between several serum cytokines shown to influence adverse event development
Solid arrows indicate induction of response, dashed arrows indicate cooperation between cytokines and T lines indicate inhibition of response.
See this image and copyright information in PMC

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