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. 2014 Oct 28;3(2):90-3.
doi: 10.1016/j.lrr.2014.09.001. eCollection 2014.

Successful HLA haploidentical myeloablative stem cell transplantation for aggressive hepatosplenic alpha/beta (αβ) T-cell lymphoma

Gioacchino Catania  1 , Francesco Zallio  1 , Federico Monaco  1 , Maria Teresa Corsetti  1 , Nicol Trincheri  2 , Lisa Bonello  3 , Lia Mele  4 , Franco Dallavalle  4 , Flavia Salvi  1 , Massimo Pini  1
Affiliations

Successful HLA haploidentical myeloablative stem cell transplantation for aggressive hepatosplenic alpha/beta (αβ) T-cell lymphoma

Gioacchino Catania et al. Leuk Res Rep. .

Abstract

Hepatosplenic T cell lymphoma (HSTCL) is a type of hematologic neoplasia with a poor prognosis and a high frequency of refractoriness to conventional chemotherapy. The results obtained by high dose chemotherapy followed by autologous stem cells transplantation seem to be a more effective option but still unsatisfactory. Also the role of allogeneic stem cell transplantation is still unclear, although the few cases reported on the literature would seem to show good results in overall survival rates. In this paper, we reported the patient׳s medical history affected by a αβ variant of hepatosplenic T cell successfully rescued with a haploidentical transplant.

Keywords: Haploidentical-SCT; Hepatosplenic T-cell lymphoma; TCR rearrangement; αβ T-lymphocytes.

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Figures

Fig. 1
Fig. 1
Liver biopsy demonstrating a monomorphic, mostly intrasinusoidal, lymphoid infiltrate (arrow) composed of small to medium size cells (H&E stain, 500×).
Fig. 2
Fig. 2
PCR analysis of TCRβ gene rearrangement using BIOMED-2 protocol. Genescan clonality profiles of bone marrow aspirates at diagnosis (A) and after allogeneic stem cells transplantation (B). Clonal products (arrows) at diagnosis are no more visible at follow up after allogeneic transplantion and a different oligoclonal pattern emerge.
See this image and copyright information in PMC

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