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. 2015 Mar;19(2):206-10.
doi: 10.1111/petr.12401. Epub 2014 Nov 28.

High-risk age window for mortality in children with cystic fibrosis after lung transplantation

Don Hayes Jr  1 , Karen S McCoy, Bryan A Whitson, Heidi M Mansour, Joseph D Tobias
Affiliations

High-risk age window for mortality in children with cystic fibrosis after lung transplantation

Don Hayes Jr et al. Pediatr Transplant. 2015 Mar.

Abstract

LTx in children with CF remains controversial. The UNOS database was queried from 1987 to 2013 for CF patients <18 yr of age at time of transplant. PCHR model was used to quantify hazard of mortality. 489 recipients were included in the survival analysis. The hazard function of post-transplant mortality was plotted over attained age to identify age window of highest risk, which was 16-20 yr. Unadjusted PCHR model revealed ages immediately after the high-risk window were characterized by lower hazard of mortality (HR = 0.472; 95% CI = 0.302, 0.738; p = 0.001). After adjusting for potential confounders, the decline in mortality hazard immediately after the high-risk window remained statistically significant (HR = 0.394; 95% CI: 0.211, 0.737; p = 0.004). Hazard of mortality in children with CF after LTx was highest between 16 and 20 yr of attained age and declined thereafter.

Keywords: age; allograft failure; cystic fibrosis; lung transplantation; survival.

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