Involvement of a leukocyte adhesion receptor (LFA-1) in HIV-induced syncytium formation
- PMID: 2543075
- DOI: 10.1126/science.2543075
Involvement of a leukocyte adhesion receptor (LFA-1) in HIV-induced syncytium formation
Abstract
Cell fusion (syncytium formation) is a major cytopathic effect of infection by human immunodeficiency virus (HIV) and may also represent an important mechanism of CD4+ T-cell depletion in individuals infected with HIV. Syncytium formation requires the interaction of CD4 on the surface of uninfected cells with HIV envelope glycoprotein gp120 expressed on HIV-infected cells. However, several observations suggest that molecules other than CD4 play a role in HIV-induced cell fusion. The leukocyte adhesion receptor LFA-1 is involved in a broad range of leukocyte interactions mediated by diverse receptor-ligand systems including CD4-class II major histocompatibility complex (MHC) molecules. Possible mimicry of class II MHC molecules by gp120 in its interaction with CD4 prompted an examination of the role of LFA-1 in HIV-induced cell fusion. A monoclonal antibody against LFA-1 completely inhibited HIV-induced syncytium formation. The antibody did not block binding of gp120 to CD4. This demonstrates that a molecule other than CD4 is also involved in cell fusion mediated by HIV.
Similar articles
-
HIV-infected cells are killed by rCD4-ricin A chain.Science. 1988 Nov 25;242(4882):1166-8. doi: 10.1126/science.2847316. Science. 1988. PMID: 2847316
-
Adhesion mediated by intercellular adhesion molecule 1 attenuates the potency of antibodies that block HIV-1 gp160-dependent syncytium formation.AIDS Res Hum Retroviruses. 1994 May;10(5):585-93. doi: 10.1089/aid.1994.10.585. AIDS Res Hum Retroviruses. 1994. PMID: 7917519
-
Functional epitope analysis of the human CD11a/CD18 molecule (LFA-1, lymphocyte function-associated antigen 1) involved in HIV-1-induced syncytium formation.Scand J Immunol. 1991 Oct;34(4):461-70. doi: 10.1111/j.1365-3083.1991.tb01569.x. Scand J Immunol. 1991. PMID: 1718027
-
Characterization of CD4 glycoprotein determinant-HIV envelope protein interactions: perspectives for analog and vaccine development.Crit Rev Immunol. 1988;8(4):315-39. Crit Rev Immunol. 1988. PMID: 2850890 Review.
-
The CD4 antigen: physiological ligand and HIV receptor.Cell. 1988 Mar 11;52(5):631-3. doi: 10.1016/0092-8674(88)90397-2. Cell. 1988. PMID: 2830988 Review. No abstract available.
Cited by
-
Human immunodeficiency virus type 1 replication in dendritic cell-T-cell cocultures is increased upon incorporation of host LFA-1 due to higher levels of virus production in immature dendritic cells.J Virol. 2007 Jul;81(14):7672-82. doi: 10.1128/JVI.02810-06. Epub 2007 May 9. J Virol. 2007. PMID: 17494076 Free PMC article.
-
MFR, a putative receptor mediating the fusion of macrophages.Mol Cell Biol. 1998 Nov;18(11):6213-23. doi: 10.1128/MCB.18.11.6213. Mol Cell Biol. 1998. PMID: 9774638 Free PMC article.
-
Stimulation of virus production and induction of self-syncytium formation in human T-cell leukemia virus type I- and type II-infected T cells by 12-O-tetradecanoylphorbol-13-acetate.J Virol. 1994 Jul;68(7):4695-9. doi: 10.1128/JVI.68.7.4695-4699.1994. J Virol. 1994. PMID: 8207847 Free PMC article.
-
Proteinase-resistant factors in human erythrocyte membranes mediate CD4-dependent fusion with cells expressing human immunodeficiency virus type 1 envelope glycoproteins.J Virol. 1995 Feb;69(2):1013-8. doi: 10.1128/JVI.69.2.1013-1018.1995. J Virol. 1995. PMID: 7815477 Free PMC article.
-
CD4 immunoadhesin, but not recombinant soluble CD4, blocks syncytium formation by human immunodeficiency virus type 2-infected lymphoid cells.J Virol. 1990 Oct;64(10):5194-8. doi: 10.1128/JVI.64.10.5194-5198.1990. J Virol. 1990. PMID: 2398542 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous