Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Nov 28;6(11):874-80.
doi: 10.4329/wjr.v6.i11.874.

Impact of dose calculation algorithm on radiation therapy

Wen-Zhou Chen  1 , Ying Xiao  1 , Jun Li  1
Affiliations
Review

Impact of dose calculation algorithm on radiation therapy

Wen-Zhou Chen et al. World J Radiol. .

Abstract

The quality of radiation therapy depends on the ability to maximize the tumor control probability while minimize the normal tissue complication probability. Both of these two quantities are directly related to the accuracy of dose distributions calculated by treatment planning systems. The commonly used dose calculation algorithms in the treatment planning systems are reviewed in this work. The accuracy comparisons among these algorithms are illustrated by summarizing the highly cited research papers on this topic. Further, the correlation between the algorithms and tumor control probability/normal tissue complication probability values are manifested by several recent studies from different groups. All the cases demonstrate that dose calculation algorithms play a vital role in radiation therapy.

Keywords: Algorithm; Dose calculation; Normal tissue complication probability; Radiation therapy; Tumor control probability.

PubMed Disclaimer

References

    1. International Commission on Radiation Units and Measurements (ICRU) Determination of absorbed dose in a patient irradiated by beams of X or gamma rays in radiotherapy procedures. ICRU Report 24. Washington (DC): ICRU; 1976. p. 67.
    1. AAPM . The American Association of Physicists in Medicine (AAPM) Report 85 Tissue inhomogeneity corrections for MV photon beams. USA: Report of Task Group No. 65 of AAPM; 2004.
    1. Metcalfe P, Kron T, Hoban P. The physics of radiotherapy x-rays and electrons. Madison, WI: Medical Physics Publishing; 2007.
    1. Knöös T, Wieslander E, Cozzi L, Brink C, Fogliata A, Albers D, Nyström H, Lassen S. Comparison of dose calculation algorithms for treatment planning in external photon beam therapy for clinical situations. Phys Med Biol. 2006;51:5785–5807. - PubMed
    1. Fogliata A, Vanetti E, Albers D, Brink C, Clivio A, Knöös T, Nicolini G, Cozzi L. On the dosimetric behaviour of photon dose calculation algorithms in the presence of simple geometric heterogeneities: comparison with Monte Carlo calculations. Phys Med Biol. 2007;52:1363–1385. - PubMed

LinkOut - more resources