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. 2014 Dec 1;1(4):309-319.
doi: 10.1007/s40429-014-0037-4.

Recent Insights into the Neurobiology of Impulsivity

Marci R Mitchell  1 , Marc N Potenza  2
Affiliations

Recent Insights into the Neurobiology of Impulsivity

Marci R Mitchell et al. Curr Addict Rep. .

Abstract

Impulsivity is associated with various psychopathologies, and elevated impulsivity is typically disadvantageous. This manuscript reviews recent investigations into the neurobiology of impulsivity using human imaging techniques and animal models. Both human imaging and preclinical pharmacological manipulations have yielded important insights into the neurobiological underpinnings of impulsivity. A more thorough understanding of the complex neurobiology underlying aspects of impulsivity may provide insight into new treatment options that target elevated impulsivity and psychopathologies such as addictions.

Keywords: delay discounting; human; impulsivity; neuroimaging; rodent; translational.

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Conflict of interest statement

Conflict of Interest

Marci R. Mitchell does not have any conflicts of interest to declare.

The authors report no conflicts of interest. Dr. Potenza has received financial support or compensation for the following: Dr. Potenza has consulted for and advised Boehringer Ingelheim, Lundbeck, Ironwood, iNSYS and Shire; has financial interests in Somaxon; has received research support from the National Institutes of Health, Veteran’s Administration, Mohegan Sun Casino, the National Center for Responsible Gaming and its affiliated Institute for Research on Gambling Disorders, and Forest Laboratories pharmaceuticals; has participated in surveys, mailings or telephone consultations related to drug addiction, impulse control disorders or other health topics; has consulted for gambling and legal entities on issues related to addictions or impulse control disorders; has provided clinical care in the Connecticut Department of Mental Health and Addiction Services Problem Gambling Services Program; has performed grant reviews for the National Institutes of Health and other agencies; has guest-edited journal sections; has given academic lectures in grand rounds, CME events and other clinical or scientific venues; and has generated books or book chapters for publishers of mental health texts. The manuscript was generated independently of these efforts and while some of the thematic content (relating to impulsivity and addictions) may be shared, they represent independent endeavors.

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